Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury

被引：205
作者：
Abe, K [1 ]
机构：
[1] Okayama Univ, Sch Med, Dept Neurol, Okayama 7008558, Japan
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2000年 / 20卷 / 10期
关键词：
neurotrophic factor; gene therapy; neural stem cell; transplantation;
D O I：
10.1097/00004647-200010000-00001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Development of neuronal and glial cells and their maintenance are under control of neurotrophic factors (NTFs). An exogenous administration of NTFs protects extremely sensitive brain tissue from ischemic damage. On the other hand, it is now known that neural stem cells are present in normal adult brain, and have a potential to compensate and recover neural functions that were lost due to ischemic stroke. These stem cells are also under control of NTFs to differentiate into a certain species of neural cells. Thus, the purpose of this review is to summarize the present understanding of the role of NTFs in normal and ischemic brain and the therapeutic potential of NTF protein itself or gene therapy, and then to summarize the role of NTFs in stem cell differentiation and a possible therapeutic potential with the neural stem cells against ischemic brain injury.
引用
收藏
页码：1393 / 1408
页数：16
相关论文
共 97 条
[61]   In vivo transfection of cis element ''decoy'' against nuclear factor-kappa B binding site prevents myocardial infarction [J].
Morishita, R ;
Sugimoto, T ;
Aoki, M ;
Kida, I ;
Tomita, N ;
Moriguchi, A ;
Maeda, K ;
Sawa, Y ;
Kaneda, Y ;
Higaki, J ;
Ogihara, T .
NATURE MEDICINE, 1997, 3 (08) :894-899
[62]   Novel therapeutic strategy for atherosclerosis - Ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression [J].
Morishita, R ;
Yamada, S ;
Yamamoto, K ;
Tomita, N ;
Kida, I ;
Sakurabayashi, I ;
Kikuchi, A ;
Kaneda, Y ;
Lawn, R ;
Higaki, J ;
Ogihara, T .
CIRCULATION, 1998, 98 (18) :1898-1904
[63]   THE BASIC SCIENCE OF GENE-THERAPY [J].
MULLIGAN, RC .
SCIENCE, 1993, 260 (5110) :926-932
[64]   ESTABLISHMENT AND CHARACTERIZATION OF A MULTIPOTENTIAL NEURAL CELL-LINE THAT CAN CONDITIONALLY GENERATE NEURONS, ASTROCYTES, AND OLIGODENDROCYTES IN-VITRO [J].
NAKAFUKU, M ;
NAKAMURA, S .
JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 41 (02) :153-168
[65]  
Nakagawa Y, 1996, DEVELOPMENT, V122, P2449
[66]   Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia [J].
Naski, MC ;
Wang, Q ;
Xu, JS ;
Ornitz, DM .
NATURE GENETICS, 1996, 13 (02) :233-237
[67]  
NOMURA M, 1995, J BIOL CHEM, V270, P28316
[68]   PLASMID DNAS DIRECTLY INJECTED INTO MOUSE-BRAIN WITH LIPOFECTIN CAN BE INCORPORATED AND EXPRESSED BY BRAIN-CELLS [J].
ONO, T ;
FUJINO, Y ;
TSUCHIYA, T ;
TSUDA, M .
NEUROSCIENCE LETTERS, 1990, 117 (03) :259-263
[69]  
PALLELA TD, 1989, GENE, V80, P137
[70]  
Parent JM, 1997, J NEUROSCI, V17, P3727
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