Antitumor Activities and Immunomodulatory Effects of Ginseng Neutral Polysaccharides in Combination with 5-Fluorouracil

被引：85
作者：
Ni, Weihua [1 ]
Zhang, Xu [1 ]
Wang, Bo [1 ,2 ]
Chen, Yan [1 ,3 ]
Han, Han [1 ]
Fan, Yuying [1 ]
Zhou, Yifa [1 ]
Tai, Guihua [1 ]
机构：
[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China
[2] Beihua Univ, Coll Chem & Biol, Jilin, Peoples R China
[3] Baicheng Med Coll, Baicheng, Peoples R China
来源：
JOURNAL OF MEDICINAL FOOD | 2010年 / 13卷 / 02期
基金：
中国国家自然科学基金;
关键词：
antitumor activity; chemoprotective effect; ginseng; immunological activity; polysaccharides; BIOLOGICAL RESPONSE MODIFIERS; MACROPHAGE ACTIVATION; ACIDIC POLYSACCHARIDE; PANAX-GINSENG; IN-VIVO; CHONDRUS-OCELLATUS; PHELLINUS-LINTEUS; BETA-GLUCAN; IMMUNOTHERAPY; MECHANISM;
D O I：
10.1089/jmf.2009.1119
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A neutral polysaccharide fraction (WGPN) prepared from Panax ginseng C. A. Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) tumor-bearing mice by intragastric administration. WGPN alone inhibited S180 tumor growth in a bell-shaped dose-response curve, and the combination with 5-FU showed a synergistic effect. Studies of various immunological activities in S180-bearing mice revealed that WGPN stimulated the proliferation of lymphocytes, increased natural killer cell cytotoxicity, enhanced the phagocytosis and nitric oxide production by macrophages, and increased the level of tumor necrosis factor-a in serum. In combination with 5-FU, WGPN mitigated damage to the immune system caused by 5-FU in S180-bearing mice. These results suggest that WGPN might be a potential adjuvant for chemotherapeutic drugs.
引用
收藏
页码：270 / 277
页数：8
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