A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H

被引：37

作者：

Dat, Nguyen Tien

Bae, KiHwan

Wamiru, Antony

McMahon, James B.

Le Grice, Stuart F. J.

Bona, Marion

Beutler, John A.

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] NCI, Mol Targets Dev Program, HIV Drug Resistance Program, Frederick, MD 21702 USA

[3] NCI, SAIC Frederick, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 05期

关键词：

D O I：

10.1021/np060359m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 mu M, respectively.

引用

页码：839 / 841

页数：3

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