N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide

被引：8

作者：

Coghi, Paolo ^{[1
,2
]}

Ng, Jerome P. L. ^{[2
,3
]}

Nasim, Ali Adnan ^{[2
,3
]}

Wong, Vincent Kam Wai ^{[2
,3
]}

机构：

[1] Macau Univ Sci & Technol, Sch Pharm, Macau 999078, Peoples R China

[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[3] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Dr Nehers Biophys Lab Innovat Drug Discovery, Macau 999078, Peoples R China

来源：

MOLBANK | 2021年 / 2021卷 / 02期

关键词：

1,2,3-triazole; anticancer; aminoquinoline; hybrid compound; ANTIMALARIAL; HYBRIDS; DESIGN;

D O I：

10.3390/M1213

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide-alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (H-1-NMR), carbon-13 nuclear magnetic resonance (C-13-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.

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页数：6

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