Eph receptors and ephrins in cancer: bidirectional signalling and beyond

被引：993

作者：

Pasquale, Elena B. ^{[1
,2
]}

机构：

[1] Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TYROSINE KINASE EPHB4; ENDOTHELIAL PROGENITOR CELLS; GROWTH-FACTOR RECEPTOR; INHIBITS TUMOR-GROWTH; HUMAN PROSTATE-CANCER; COLORECTAL-CANCER; IN-VIVO; MELANOMA-CELLS; OVARIAN-CARCINOMA; BREAST-CANCER;

D O I：

10.1038/nrc2806

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Eph receptors and ephrins have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumour growth, invasiveness, angiogenesis and metastasis in vivo. However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer.

引用

页码：165 / 180

页数：16

共 227 条

[1] Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors [J].

Alazzouzi, H ;

Davalos, V ;

Kokko, A ;

Domingo, E ;

Woerner, SM ;

Wilson, AJ ;

Konrad, L ;

Laiho, P ;

Espín, E ;

Armengol, M ;

Imai, K ;

Yamamoto, H ;

Mariadason, JM ;

Gebert, JF ;

Aaltonen, LA ;

Schwartz, S ;

Arango, D .

CANCER RESEARCH, 2005, 65 (22) :10170-10173

[2] Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers [J].

Alford, Spencer C. ;

Bazowski, Jessa ;

Lorimer, Heather ;

Elowe, Sabine ;

Howard, Perry L. .

EXPERIMENTAL CELL RESEARCH, 2007, 313 (20) :4170-4179

[3] Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype [J].

Almog, Nava ;

Ma, Lili ;

Raychowdhury, Raktima ;

Schwager, Christian ;

Erber, Ralf ;

Short, Sarah ;

Hlatky, Lynn ;

Vajkoczy, Peter ;

Huber, Peter E. ;

Folkman, Judah ;

Abdollahi, Amir .

CANCER RESEARCH, 2009, 69 (03) :836-844

[4]

Alves PMS, 2003, CANCER RES, V63, P8476

[5] Hsp90 Is an Essential Regulator of EphA2 Receptor Stability and Signaling: Implications for Cancer Cell Migration and Metastasis [J].

Annamalai, Balasubramaniam ;

Liu, Xueguang ;

Gopal, Udhayakumar ;

Isaacs, Jennifer S. .

MOLECULAR CANCER RESEARCH, 2009, 7 (07) :1021-1032

[6] Eph/ephrin signaling: networks [J].

Arvanitis, Dina ;

Davy, Alice .

GENES & DEVELOPMENT, 2008, 22 (04) :416-429

[7] Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines [J].

Bardelle, Catherine ;

Coleman, Tanya ;

Cross, Darren ;

Davenport, Sara ;

Kettle, Jason G. ;

Ko, Eun Jung ;

Leach, Andrew G. ;

Mortlock, Andrew ;

Read, Jon ;

Roberts, Nicola J. ;

Robins, Peter ;

Williams, Emma J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (21) :5717-5721

[8] Inhibitors of the tyrosine kinase EphB4.: Part 1:: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines [J].

Bardelle, Catherine ;

Cross, Darren ;

Davenport, Sara ;

Kettle, Jason G. ;

Ko, Eun Jung ;

Leach, Andrew G. ;

Mortlock, Andrew ;

Read, Jon ;

Roberts, Nicola J. ;

Robins, Peter ;

Williams, Emma J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (09) :2776-2780

[9] Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis [J].

Barrios, A ;

Poole, RJ ;

Durbin, L ;

Brennan, C ;

Holder, N ;

Wilson, SW .

CURRENT BIOLOGY, 2003, 13 (18) :1571-1582

[10] B61 IS A LIGAND FOR THE ECK RECEPTOR PROTEIN-TYROSINE KINASE [J].

BARTLEY, TD ;

HUNT, RW ;

WELCHER, AA ;

BOYLE, WJ ;

PARKER, VP ;

LINDBERG, RA ;

LU, HS ;

COLOMBERO, AM ;

ELLIOTT, RL ;

GUTHRIE, BA ;

HOLST, PL ;

SKRINE, JD ;

TOSO, RJ ;

ZHANG, M ;

FERNANDEZ, E ;

TRAIL, G ;

VARNUM, B ;

YARDEN, Y ;

HUNTER, T ;

FOX, GM .

NATURE, 1994, 368 (6471) :558-560

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