Radiotherapy for cutaneous melanoma: current and future applications

被引：27
作者：
Gorayski, Peter [1 ]
Burmeister, Bryan [1 ,2 ]
Foote, Matthew [1 ,2 ]
机构：
[1] Princess Alexandra Hosp, Dept Radiat Oncol, Woolloongabba, Qld 4102, Australia
[2] Univ Queensland, Sch Med, Brisbane, Qld 4072, Australia
来源：
FUTURE ONCOLOGY | 2015年 / 11卷 / 03期
关键词：
cutaneous; melanoma; radiation therapy; radiotherapy; targeted therapies; METASTATIC MALIGNANT-MELANOMA; RADIATION-THERAPY; BRAIN METASTASES; ADJUVANT RADIOTHERAPY; NEUROTROPIC MELANOMA; LENTIGO MALIGNA; FRACTIONATED RADIOTHERAPY; PROGNOSTIC-FACTORS; EXCISION MARGINS; NODAL SURGERY;
D O I：
10.2217/fon.14.300
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cutaneous malignant melanoma remains a significant health burden worldwide despite advances in the management of locoregionally advanced and metastatic disease. Historically, the efficacy of radiation therapy (RT) has been questioned due to the perceived radioresistance of melanoma cancer cells in vitro. Nowadays, RT has limited indications for primary disease, but is used for high-risk nodal disease and in the palliative setting. This review article outlines the current role of RT for melanoma and its expanding role in oligometastatic disease scenarios as an alternative approach to surgery and highlights potential future applications to harness RT interaction with immunomodulatory targeted therapies.
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收藏
页码：525 / 534
页数：10
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