Tiapride induced rhabdomyolysis in Parkinson's disease

Rhabdomyolysis can be defined as the destruction of striated muscle cells provoked by many causes. A typical clinical feature is muscular pain, often accompanied with impaired conciousness. The laboratory diagnosis is based on the occurrence of increased serum level of creatinkinase and myoglobine. We present a case of a 75-year-old male with Parkinson's disease where signs of rhabdomyolysis appeared several hours after the intravenous application of tiapride (100 mg). The impairment of consciousness and muscular pain were the first clinical symptoms of rhabdomyolysis in our patient. The increased levels of creatinekinase (max. 62.41 mu kat/l) and myoglobine (max. 3412 mu tg/l) were found in serum. Clinically, it is important to emphasize that rhabdomyolysis can be caused by several commonly used doses of atypical antipsychotics, for example, tiapride.