N-Alkylacrylamide copolymers with (meth)acrylamide derivatives of cholic acid:: synthesis and thermosensitivity

被引：48

作者：

Avoce, D ^{[1
]}

Liu, HY ^{[1
]}

Zhu, XX ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

POLYMER | 2003年 / 44卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

N-alkylacrylamide copolymers; bile acids; thermosensitive polymers;

D O I：

10.1016/S0032-3861(02)00868-6

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Copolymers of N-alkylacrylamides with acrylamide or methacrylamide derivatives of cholic acid have been prepared to obtain copolymers with desired thermosensitivity and enhanced hydrophilicity. The thermosensitivity of these copolymers depends on their chemical composition as studied by microcalorimetry, differential scanning calorimetry and UV-visible spectroscopy. The lower critical solution temperature and the enthalpy change of the phase separation process of the copolymers in water decreased with increasing content of the bile acid residues in the polymers. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1081 / 1087

页数：7

共 7 条

[1] Block and Random Copolymers Bearing Cholic Acid and Oligo(ethylene glycol) Pendant Groups: Aggregation, Thermosensitivity, and Drug Loading
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