Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

被引：191

作者：

Palmieri, Alessandro ^{[1
]}

Petrini, Marino ^{[1
]}

Shaikh, Rafik R. ^{[1
]}

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 06期

关键词：

FRIEDEL-CRAFTS REACTION; SUBSTITUTED N-HYDROXYINDOLES; EFFICIENT MICHAEL ADDITION; SOLVENT-FREE CONDITIONS; ENANTIOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; PHOSPHORIC-ACID; ALDEHYDES; DERIVATIVES; ALKYLATION;

D O I：

10.1039/b919891a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Elimination of suitable leaving groups from 3-substituted indoles under basic or acidic conditions readily provides alkylideneindolenine intermediates that may react with a large variety of nucleophilic reagents. This article highlights some recent developments of this synthetic approach for the preparation of functionalized indole derivatives.

引用

页码：1259 / 1270

页数：12

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