Increased efficiency of homologous recombination in ES cells by cleavage at both ends of homology in the targeting vector

被引：5

作者：

Sarig, R ^{[1
]}

Mezger-Lallemand, V ^{[1
]}

Leibovitz, S ^{[1
]}

Nudel, U ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Moelcular Cell Biol, Rehovot, Israel

来源：

TRANSGENIC RESEARCH | 2000年 / 9卷 / 02期

关键词：

Dp71; dystrophin gene; gene targeting; homologous recombination; vector DNA;

D O I：

10.1023/A:1008999109862

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：79 / 80

页数：2

共 6 条

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[3]

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[5] Targeted inactivation of Dp71, the major non-muscle product of the DMD gene: differential activity of the Dp71 promoter during development [J].

Sarig, R ;

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Fuchs, O ;

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Nudel, U .

HUMAN MOLECULAR GENETICS, 1999, 8 (01) :1-10

[6] POSITIVE GENETIC SELECTION FOR GENE DISRUPTION IN MAMMALIAN-CELLS BY HOMOLOGOUS RECOMBINATION [J].

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SHARP, PA .

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