Transdermal Delivery of Crocin Using Bacterial Nanocellulose Membrane

被引：35

作者：

Abba, Mustapha ^{[1
,2
]}

Ibrahim, Zaharah ^{[1
]}

Chong, Chun Shiong ^{[1
]}

Zawawi, Nurliyana Ahmad ^{[1
]}

Kadir, Mohammed Rafiq Abdul ^{[3
]}

Yusof, Abdul Halim Mohd ^{[4
]}

Abd Razak, Saiful Izwan ^{[3
,5
]}

机构：

[1] Univ Teknol Malaysia, Fac Sci, Dept Biosci, Skudai 81300, Johor, Malaysia

[2] Bauchi State Univ, Fac Sci, Dept Microbiol, PMB 65, Gadau, Bauchi State, Nigeria

[3] Univ Teknol Malaysia, Fac Engn, Sch Biomed Engn & Hlth Sci, Skudai 81300, Johor, Malaysia

[4] Univ Teknol Malaysia, Fac Engn, Sch Chem & Energy Engn, Skudai 81300, Johor, Malaysia

[5] Univ Teknol Malaysia, Ctr Adv Composite Mat, Skudai 81300, Johor, Malaysia

来源：

FIBERS AND POLYMERS | 2019年 / 20卷 / 10期

关键词：

Bacterial nanocellulose; Transdermal drug delivery; Saffron; Crocin; Nanocellulose; Franz diffusion; CELLULOSE MEMBRANES; GLUCONACETOBACTER-XYLINUS; SAFFRON; RELEASE; BIOSYNTHESIS; TOXICITY; FUTURE;

D O I：

10.1007/s12221-019-9076-8

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

This work reports the inclusion of crocin (an active agent of saffron) into bacterial nanocellulose (BNC) membrane for transdermal drug delivery. The BNC showed good uptake of the crocin based on the swelling studies and vibrational peaks of the FTIR spectra. Surface morphology of the crocin loaded BNC showed that the fibrous nano feature was still intact with no fiber damages. The crocin release via direct dissolution showed typical burst release. Franz diffusion test revealed stable and prolong drug permeation. Partition coefficient of the BNC-crocin via mice epidermal skin diffusion was found to be 2.44x10(-4) cm(-2) min(-1) with the average mass flux of 0.53 cm(-2) min(-1). This facile method of utilizing BNC for the carrier of crocin can be useful for administrating other water soluble active compound. Thus BNC opens up choices for the delivery of crocin for medicinal purposes.

引用

页码：2025 / 2031

页数：7

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