Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

被引：72

作者：

Ashcroft, Frances M. ^{[1
,2
]}

Rohm, Maria ^{[1
,2
]}

Clark, Anne ^{[3
]}

Brereton, Melissa F. ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Parks Rd, Oxford OX1 3PT, England

[2] Univ Oxford, OXION, Parks Rd, Oxford OX1 3PT, England

[3] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Churchill Hosp, Oxford OX3 7LJ, England

来源：

CELL METABOLISM | 2017年 / 26卷 / 01期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

INSULIN-RELEASE; GLUCOSE; METABOLISM; ACCUMULATION; ISLETS; GENE; AUTOPHAGY; SYNTHASE; PHOSPHORYLASE; EXPRESSION;

D O I：

10.1016/j.cmet.2017.05.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Elevated plasma glucose leads to pancreatic beta cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting b cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in b cells in normoglycemia and in diabetes.

引用

页码：17 / 23

页数：7

共 78 条

[1] Glycogen metabolism in the glucose-sensing and supply-driven -cell [J].

Andersson, Lotta E. ;

Nicholas, Lisa M. ;

Filipsson, Karin ;

Sun, Jiangming ;

Medina, Anya ;

Al-Majdoub, Mahmoud ;

Fex, Malin ;

Mulder, Hindrik ;

Spegel, Peter .

FEBS LETTERS, 2016, 590 (23) :4242-4251

[2] Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients [J].

Anello, M ;

Lupi, R ;

Spampinato, D ;

Piro, S ;

Masini, M ;

Boggi, U ;

Del Prato, S ;

Rabuazzo, AM ;

Purrello, F ;

Marchetti, P .

DIABETOLOGIA, 2005, 48 (02) :282-289

[3]

[Anonymous], WIEN KLEIN WOCHENSCH

[4] ATP-sensitive K+ channels and disease:: from molecule to malady [J].

Ashcroft, Frances M. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (04) :E880-E889

[5] GLUCOSE-6-PHOSPHATASE ACTIVITY OF MOUSE PANCREATIC ISLETS [J].

ASHCROFT, SJ ;

RANDLE, PJ .

NATURE, 1968, 219 (5156) :857-&

[6] ENZYMES OF GLUCOSE METABOLISM IN NORMAL MOUSE PANCREATIC ISLETS [J].

ASHCROFT, SJ ;

RANDLE, PJ .

BIOCHEMICAL JOURNAL, 1970, 119 (01) :5-&

[7] INTERRELATIONSHIP OF ISLET METABOLISM, ADENOSINE-TRIPHOSPHATE CONTENT AND INSULIN RELEASE [J].

ASHCROFT, SJ ;

WEERASINGHE, LC ;

RANDLE, PJ .

BIOCHEMICAL JOURNAL, 1973, 132 (02) :223-231

[8] PENTOSE CYCLE AND INSULIN RELEASE IN MOUSE PANCREATIC-ISLETS [J].

ASHCROFT, SJ ;

BASSETT, JM ;

WEERASIN.LC ;

RANDLE, PJ .

BIOCHEMICAL JOURNAL, 1972, 126 (03) :525-&

[9] Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations [J].

Bensellam, M. ;

Van Lommel, L. ;

Overbergh, L. ;

Schuit, F. C. ;

Jonas, J. C. .

DIABETOLOGIA, 2009, 52 (03) :463-476

[10] A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels [J].

Bouatia-Naji, Nabila ;

Rocheleau, Ghislain ;

Van Lommel, Leentje ;

Lemaire, Katleen ;

Schuit, Frans ;

Cavalcanti-Proenca, Christine ;

Marchand, Marion ;

Hartikainen, Anna-Liisa ;

Sovio, Ulla ;

De Graeve, Franck ;

Rung, Johan ;

Vaxillaire, Martine ;

Tichet, Jean ;

Marre, Michel ;

Balkau, Beverley ;

Weill, Jacques ;

Elliott, Paul ;

Jarvelin, Marjo-Riitta ;

Meyre, David ;

Polychronakos, Constantin ;

Dina, Christian ;

Sladek, Robert ;

Froguel, Philippe .

SCIENCE, 2008, 320 (5879) :1085-1088

← 1 2 3 4 5 6 7 8 →