Synthesis of ribavirin 2'-Me-C-nucleoside analogues

被引：10
作者：
Cosson, Fanny [1 ]
Faroux, Aline [1 ]
Baltaze, Jean-Pierre [2 ]
Farjon, Jonathan [3 ]
Guillot, Regis [2 ]
Uziel, Jacques [1 ]
Lubin-Germain, Nadege [1 ]
机构：
[1] Univ Cergy Pontoise, Lab Chim Biol, 5 Mail Gay Lussac, Cergy Pontoise, France
[2] Univ Paris 11, ICMMO, UMR CNRS 8182, 15 Rue Georges Clemenceau, Orsay, France
[3] Univ Nantes, Lab CEISAM, UMR 6230, 2 Rue Houssiniere, Nantes, France
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 13卷
关键词：
alkynylation; antiviral; cancer; C-nucleosides; ribavirin; HEPATITIS-C VIRUS; PLUS RIBAVIRIN; RANDOMIZED-TRIAL; HUH-7; CELLS; NUCLEOSIDES; NUCLEOTIDES; SOFOSBUVIR; INHIBITOR; INFECTION; REPLICON;
D O I：
10.3762/bjoc.13.74
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2'-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.
引用
收藏
页码：755 / 761
页数：7
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