Role of genetic factors and inflammation in age-related macular degeneration

被引：43
作者：
Moshfeghi, Darius M. [1 ]
Blumenkranz, Mark S. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Ophthalmol, Stanford, CA 94305 USA
来源：
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2007年 / 27卷 / 03期
关键词：
age-related macular degeneration; candidate gene; complement factor H; LOC387715; Y402H; 1q32; 6p21; 10q26; COMPLEMENT FACTOR-H; CHLAMYDIA-PNEUMONIAE INFECTION; C-REACTIVE PROTEIN; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; APOLIPOPROTEIN-E; Y402H VARIANT; GEOGRAPHIC ATROPHY; STRONG ASSOCIATION; CIGARETTE-SMOKING; ABCR GENE;
D O I：
10.1097/IAE.0b013e31802e3e9b
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 11q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.
引用
收藏
页码：269 / 275
页数：7
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