Molecular Logic Gates Connected through DNA Four-Way Junctions

被引:62
作者
Lake, Alex [1 ]
Shang, Stephen [1 ]
Kolpashchikov, Dmitry M. [1 ]
机构
[1] Univ Cent Florida, Dept Chem, Orlando, FL 32816 USA
关键词
DNA; logic gates; molecular devices; nanotechnology; oligonucleotides; HYBRIDIZATION KINETICS; RECOGNITION; CIRCUITS; SHAPES;
D O I
10.1002/anie.200907135
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) Simply logical: This study introduces connectable molecular logic gates made of DNA. Transfer of oligonucleotide input/ output signals from gate to gate is achieved by the formation of complexes that contain DNA four-way junctions when the signal is high; these complexes disassemble when the signal is low. © 2010 Wlley-VCH Verlag GmbH &. Co. KGaA, Weinheim.
引用
收藏
页码:4459 / 4462
页数:4
相关论文
共 29 条
[1]  
[Anonymous], 1993, DIGITAL COMPUTER ELE
[2]   Chemistry meets computing [J].
Ball, P .
NATURE, 2000, 406 (6792) :118-120
[3]   Chemical approaches to nanometre-scale logic gates [J].
de Silva, A. Prasanna ;
Leydet, Yoann ;
Lincheneau, Christophe ;
McClenaghan, Nathan D. .
JOURNAL OF PHYSICS-CONDENSED MATTER, 2006, 18 (33) :S1847-S1872
[4]   A MOLECULAR PHOTOIONIC AND GATE BASED ON FLUORESCENT SIGNALING [J].
DE SILVA, AP ;
GUNARATNE, HQN ;
MCCOY, CP .
NATURE, 1993, 364 (6432) :42-44
[5]   New insight into the recognition of branched DNA structure by junction-resolving enzymes [J].
Declais, Anne-Cecile ;
Lilley, David M. J. .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2008, 18 (01) :86-95
[6]   Self-assembly of DNA into nanoscale three-dimensional shapes [J].
Douglas, Shawn M. ;
Dietz, Hendrik ;
Liedl, Tim ;
Hoegberg, Bjoern ;
Graf, Franziska ;
Shih, William M. .
NATURE, 2009, 459 (7245) :414-418
[7]   A binary DNA probe for highly specific nucleic acid recognition [J].
Kolpashchikov, Dmitry M. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (32) :10625-10628
[8]   Potassium-Lead-Switched G-Quadruplexes: A New Class of DNA Logic Gates [J].
Li, Tao ;
Wang, Erkang ;
Dong, Shaojun .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (42) :15082-+
[9]   Analysis of branched nucleic acid structure using comparative gel electrophoresis [J].
Lilley, David M. J. .
QUARTERLY REVIEWS OF BIOPHYSICS, 2008, 41 (01) :1-39
[10]   Structures of helical junctions in nucleic acids [J].
Lilley, DMJ .
QUARTERLY REVIEWS OF BIOPHYSICS, 2000, 33 (02) :109-159