Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells

被引：203

作者：

Wang, Yao ^{[1
]}

Zhang, Wen-ying ^{[2
]}

Han, Qing-wang ^{[1
]}

Liu, Yang ^{[3
]}

Dai, Han-ren ^{[1
]}

Guo, Ye-lei ^{[1
]}

Bo, Jian ^{[4
]}

Fan, Hui ^{[2
]}

Zhang, Yan ^{[2
]}

Zhang, Ya-jing ^{[2
]}

Chen, Mei-xia ^{[2
]}

Feng, Kai-chao ^{[2
]}

Wang, Quan-shun ^{[4
]}

Fu, Xiao-bing ^{[1
]}

Han, Wei-dong ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Sch Life Sci, Inst Basic Med, Dept Immunol, Beijing 100853, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Biotherapeut, Beijing 100853, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Hematol, Beijing 100853, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing 100853, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2014年 / 155卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Anti-CD20 chimeric antigen receptor (CAR) T cells; Refractory advanced; Diffuse large B-cell lymphoma (DLBCL); Delayed toxicities; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; CLINICAL-TRIAL; CANCER; PERSISTENCE; THERAPY; REGRESSION; MALIGNANCY; DEPLETION; EFFICACY;

D O I：

10.1016/j.clim.2014.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted a trial testing a CD20-specific CAR coupled with CD137 and the CD3 zeta moiety in patients with chemotherapy refractory advanced diffuse large B cell lymphomas (DLBCL). Seven patients were enrolled. One of the two patients with no bulky tumor obtained a 14-month durable and ongoing complete remission by cell infusion only, and another attained a 6-month tumor regression. Four of five patients with bulky tumor burden were evaluable for clinical efficacy, three of which attained 3- to 6-month tumor regression. Delayed toxicities related to cell infusion are directly correlated to tumor burden and tumor-harboring sites, and mainly included cytokine release symptoms, tumor lysis symptoms, massive hemorrhage of the alimentary tract and aggressive intrapulmonary inflammation surrounding extranodal lesions. These results show firstly that anti-CD20 CART cells can cause prolonged tumor regression in combination with debulking conditioning regimens for advanced DLBCL. This study is registered at www.clinicaltrials.gov as NCT01735604. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：160 / 175

页数：16

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