Treatment choices and neuropsychological symptoms of a large cohort of early MS

被引：53

作者：

von Bismarck, Olga ^{[1
]}

Dankowski, Theresa ^{[2
]}

Ambrosius, Bjeorn ^{[1
]}

Hessler, Nicole ^{[2
]}

Antony, Gisela ^{[3
]}

Ziegler, Andreas ^{[2
,4
]}

Hoshi, Muna-Miriam ^{[5
]}

Aly, Lilian ^{[5
,6
]}

Luessi, Felix ^{[7
]}

Groppa, Sergiu ^{[7
]}

Klotz, Luisa ^{[8
]}

Meuth, Sven G. ^{[8
]}

Tackenberg, Bjorn ^{[9
]}

Stoppe, Muriel ^{[10
]}

Bergh, Florian Then ^{[10
]}

Tumani, Hayrettin ^{[11
,12
]}

Kuempfel, Tania ^{[13
]}

Stangel, Martin ^{[14
]}

Heesen, Christoph ^{[15
]}

Wildemann, Brigitte ^{[16
]}

Paul, Friedemann ^{[17
,18
]}

Bayas, Antonios ^{[19
]}

Warnke, Clemens ^{[20
,21
]}

Weber, Frank ^{[22
,23
]}

Linker, Ralf A. ^{[24
]}

Ziemann, Ulf ^{[25
]}

Zettl, Uwe K. ^{[26
]}

Zipp, Frauke ^{[7
]}

Wiendl, Heinz ^{[8
]}

Hemmer, Bernhard ^{[5
,6
]}

Gold, Ralf ^{[1
]}

Salmen, Anke ^{[1
,27
]}

机构：

[1] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany

[2] Univ Lubeck, Univ Hosp Schleswig Holstein, Inst Med Biometry & Stat, Campus Lubeck, Lubeck, Germany

[3] Philipps Univ Marburg, CIO, Marburg, Germany

[4] Univ KwaZulu Natal, Sch Math Stat & Comp Sci, Pietermaritzburg, South Africa

[5] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, Munich, Germany

[6] Johannes Gutenberg Univ Mainz, Univ Med Mainz, Munich Cluster Syst Neurol SyNergy, Mainz, Germany

[7] Johannes Gutenberg Univ Mainz, Univ Med Mainz, Dept Neurol, Mainz, Germany

[8] Univ Hosp Munster, Dept Neurol, Munster, Germany

[9] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[10] Univ Leipzig, Dept Neurol, Leipzig, Germany

[11] Univ Ulm, Dept Neurol, Ulm, Germany

[12] Clin Neurol Dietenbronn, Schwendi, Germany

[13] Ludwig Maximilian Univ Munich, Inst Clin Neuroimmunol, Munich, Germany

[14] Hannover Med Sch, Dept Neurol, Hannover, Germany

[15] Univ Klinikum Hamburg Eppendorf, Inst Neuroimmunol & Multiple Sklerose, Hamburg, Germany

[16] Heidelberg Univ, Dept Neurol, Heidelberg, Germany

[17] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[18] Charite Univ Med Berlin, Expt & Clin Res Ctr, Berlin, Germany

[19] Klinikum Augsburg, Dept Neurol, Augsburg, Germany

[20] Heinrich Heine Univ, Dept Neurol, Dusseldorf, Germany

[21] Univ Hosp Koln, Dept Neurol, Cologne, Germany

[22] Max Planck Inst Psychiat, Neurol, Munich, Germany

[23] MATERNUS Kliniken AG, Neurol Clin, Bad Oeynhausen, Germany

[24] Univ Hosp Erlangen, Dept Neurol, Erlangen, Germany

[25] Eberhard Karls Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurol & Stroke, Tubingen, Germany

[26] Univ Rostock, Dept Neurol, Rostock, Germany

[27] Univ Hosp, Inselspital Bern, Dept Neurol, Bern, Switzerland

来源：

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2018年 / 5卷 / 03期

关键词：

QUALITY-OF-LIFE; MULTIPLE-SCLEROSIS; GENERAL-POPULATION; CHRONIC FATIGUE; DEPRESSION; DISABILITY; IMPACT; RISK; IMPAIRMENT; CRITERIA;

D O I：

10.1212/NXI.0000000000000446

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To assess clinical characteristics, distribution of disease-modifying treatments (DMTs), and neuropsychological symptoms in a large cohort of patients with early-stage MS. Methods The German National MS Cohort is a multicenter prospective longitudinal cohort study that has recruited DMT-naive patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) since 2010. We evaluated their baseline characteristics and the prevalence of neuropsychological symptoms. Results Of 1,124 patients, with a 2.2: 1 female-to-male ratio and median age at onset of 31.71 years (interquartile range [IQR]: 26.06-40.33), 44.6% and 55.3% had CIS and RRMS, respectively. The median Expanded Disability Status Scale (EDSS) score at baseline was 1.5 (IQR: 1.0-2.0). A proportion of 67.8% of patients started DMT after a median time of 167.0 days (IQR 90.0-377.5) since the first manifestation. A total of 64.7% and 70.4% of the 762 patients receiving early DMT were classified as CIS and RRMS, respectively. Fatigue, depressive symptoms, and cognitive dysfunction were detected in 36.5%, 33.5%, and 14.7% of patients, respectively. Conclusion Baseline characteristics of this large cohort of patients with early, untreated MS corroborated with other cohorts. Most patients received early DMT within the first year after disease onset, irrespective of a CIS or RRMS diagnosis. Despite the low EDSS score, neuropsychological symptoms affected a relevant proportion of patients.

引用

页数：10

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