Direct cellular responses to platinum-induced DNA damage

被引：1261
作者：
Jung, Yongwon [1 ]
Lippard, Stephen J. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
CHEMICAL REVIEWS | 2007年 / 107卷 / 05期
关键词：
D O I：
10.1021/cr068207j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A review is given of the cellular processes that lead to the formation of platinum-DNA (deoxyribonucleic acid) adducts at the early events that subsequently transpire. Topics discussed include the mechanism by which platinum drugs enter the cancer cells, modification of cellular DNA by platinum-based anticancer drugs, effects of platinum-DNA adducts on the structure and function of proteins that interact directly with the genome, repair of platinum-damaged DNA, the binding mechanism of proteins to platinum-modified DNA.
引用
收藏
页码：1387 / 1407
页数：21
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