The lung mycobiome in the next-generation sequencing era

被引：52

作者：

Tipton, Laura ^{[1
,2
]}

Ghedin, Elodie ^{[2
]}

Morris, Alison ^{[3
,4
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Computat & Syst Biol, Pittsburgh, PA 15213 USA

[2] NYU, Dept Biol, New York, NY 10003 USA

[3] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA

来源：

VIRULENCE | 2017年 / 8卷 / 03期

关键词：

fungi; lung; mycobiome; next-generation sequencing; respiratory tract; RESPIRATORY-TRACT; CYSTIC-FIBROSIS; FUNGI; MICROBIOME; SAMPLES; IDENTIFICATION; BACTERIAL; IMMUNITY; DISEASE; HEALTH;

D O I：

10.1080/21505594.2016.1235671

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The fungi that reside in the human lungs represent an understudied, but medically relevant comm-unity. From the few studies published on the lung mycobiome, we find that there are fungi in both the healthy and diseased respiratory tract, that these fungi vary widely between individuals, and that there is a trend toward lower fungal diversity among individuals with disease. This review discusses the few studies of the lung mycobiome and details the challenges that accompany lung mycobiome studies. These challenges include sample collection and processing, sequence amplification and processing, and a history of multiple names for species. Some challenges may never be solved, but others can be solved with more data and additional studies of the lung mycobiome.

引用

页码：334 / 341

页数：8

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