Repigmentation through Melanocyte Regeneration in Vitiligo

被引：33

作者：

Birlea, Stanca A. ^{[1
]}

Goldstein, Nathaniel B. ^{[1
]}

Norris, David A. ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Dermatol, Anschutz Med Campus,12801 17th Ave, Aurora, CO 80045 USA

[2] Denver Dept Vet Affairs Med Ctr, Dept Dermatol, 1055 Clermont St, Denver, CO 80220 USA

来源：

DERMATOLOGIC CLINICS | 2017年 / 35卷 / 02期

关键词：

Vitiligo; Repigmentation; Melanocyte stem cell; Bulge; Hair follicle; Proliferation; Migration; Differentiation; TOPICAL CALCINEURIN INHIBITORS; OUTER ROOT SHEATH; WNT/BETA-CATENIN; HAIR-FOLLICLES; B PHOTOTHERAPY; SKIN; MIGRATION; PROLIFERATION; DIFFERENTIATION; EXPRESSION;

D O I：

10.1016/j.det.2016.11.015

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Repigmentation in vitiligo is the process that replaces, in the epidermal basal layer of vitiligo skin, the mature melanocytes that have been killed by cytotoxic T cells specific for melanocyte antigens. It consists of mobilization of melanocyte precursors in the hair follicle bulge and infundibulum to proliferate, migrate, and differentiate into mature melanocytes, moving from the hair follicle bulge to the interfollicular epidermis. The most common clinical presentation of repigmentation in vitiligo is the perifollicular pattern. The most potent stimulus for repigmentation is the UV light.

引用

页码：205 / +

页数：15

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