Results from Oritavancin Resistance Surveillance Programs (2011 to 2014): Clarification for Using Vancomycin as a Surrogate To Infer Oritavancin Susceptibility

被引：15

作者：

Jones, Ronald N. ^{[1
]}

Moeck, Greg ^{[2
]}

Arhin, Francis F. ^{[2
]}

Dudley, Michael N. ^{[3
]}

Rhomberg, Paul R. ^{[1
]}

Mendes, Rodrigo E. ^{[1
]}

机构：

[1] JMI Labs, North Liberty, IA USA

[2] Med Co, St Laurent, PQ, Canada

[3] Med Co, San Diego, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 05期

关键词：

ACUTE BACTERIAL SKIN; SINGLE-DOSE ORITAVANCIN; IN-VITRO ACTIVITIES; STAPHYLOCOCCUS-AUREUS; STRUCTURE INFECTIONS; LIPOGLYCOPEPTIDE; HOSPITALS; LY333328; AGENTS;

D O I：

10.1128/AAC.03029-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Measurement of vancomycin susceptibility has been shown to be highly predictive as a surrogate measure of oritavancin susceptibility among clinically indicated Gram-positive species. Results of studying over 30,000 pathogens (from 2011 to 2014) by cross-susceptibility analysis and determining the poor reproducibility of oritavancin-nonsusceptible results showed nearly perfect surrogate testing accuracy (99.86 to 99.94%). Any isolate of an indicated organism species with locally reproducible oritavancin- nonsusceptible results (extremely rare) should be referred to a reference laboratory for confirmation of the results and determination of the resistance mechanism.

引用

收藏

页码：3174 / 3177

页数：4

相关论文

共 26 条

[1] In Vivo Activity of Oritavancin in Animal Infection Models and Rationale for a New Dosing Regimen in Humans [J].

Ambrose, Paul G. ;

Drusano, George L. ;

Craig, William A. .

CLINICAL INFECTIOUS DISEASES, 2012, 54 :S220-S228

[2] Effect of polysorbate 80 on oritavancin binding to plastic surfaces: Implications for susceptibility testing [J].

Arhin, Francis F. ;

Sarmiento, Ingrid ;

Belley, Adam ;

McKay, Geoffrey A. ;

Draghi, Deborah C. ;

Grover, Parveen ;

Sahm, Daniel F. ;

Parr, Thomas R., Jr. ;

Moeck, Gregory .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (05) :1597-1603

[3] In vitro activities of oritavancin and comparators against meticillin-resistant Staphylococcus aureus (MRSA) isolates harbouring the novel mecC gene [J].

Arhin, Francis F. ;

Sarmiento, Ingrid ;

Moeck, Gregory .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2014, 44 (01) :65-68

[4] Comparative in vitro activity of oritavancin against recent, genetically diverse, community-associated meticillin-resistant Staphylococcus aureus (MRSA) isolates [J].

Arhin, Francis F. ;

Kurepina, Natalia ;

Sarmiento, Ingrid ;

Parr, Thomas R., Jr. ;

Moeck, Gregory ;

Kreiswirth, Barry .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2010, 35 (01) :93-94

[5] Comparative in vitro activity of oritavancin against Staphylococcus aureus strains that are resistant, intermediate or heteroresistant to vancomycin [J].

Arhin, Francis F. ;

Sarmiento, Ingrid ;

Parr, Thomas R., Jr. ;

Moeck, Gregory .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (04) :868-870

[6] Unmet Needs and Prospects for Oritavancin in the Management of Vancomycin-Resistant Enterococcal Infections [J].

Arias, Cesar A. ;

Mendes, Rodrigo E. ;

Stilwell, Matthew G. ;

Jones, Ronald N. ;

Murray, Barbara E. .

CLINICAL INFECTIOUS DISEASES, 2012, 54 :S233-S238

[7]

Clinical and Laboratory Standards Institute, 2015, M100S25 CLIN LAB STA

[8]

Clinical and Laboratory Standards Institute, 2015, M02A12 CLIN LAB STAN

[9] Single-Dose Oritavancin Versus 7-10 Days of Vancomycin in the Treatment of Gram-Positive Acute Bacterial Skin and Skin Structure Infections: The SOLO II Noninferiority Study [J].

Corey, G. Ralph ;

Good, Samantha ;

Jiang, Hai ;

Moeck, Greg ;

Wikler, Matthew ;

Green, Sinikka ;

Manos, Paul ;

Keech, Richard ;

Singh, Rajesh ;

Heller, Barry ;

Bubnova, Natalia ;

O'Riordan, William .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (02) :254-262

[10] Single-Dose Oritavancin in the Treatment of Acute Bacterial Skin Infections [J].

Corey, G. Ralph ;

Kabler, Heidi ;

Mehra, Purvi ;

Gupta, Sandeep ;

Overcash, J. Scott ;

Porwal, Ashwin ;

Giordano, Philip ;

Lucasti, Christopher ;

Perez, Antonio ;

Good, Samantha ;

Jiang, Hai ;

Moeck, Greg ;

O'Riordan, William .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (23) :2180-2190