Large-scale identification in yeast of conserved ageing genes

被引：60
作者：
Kaeberlein, M
Kennedy, BK
机构：
[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA
[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
[3] Univ Washington, Dept Med, Seattle, WA 98195 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2005年 / 126卷 / 01期
关键词：
yeast aging; replicative life span; genome-wide; calorie restriction; Sir2; LIFE-SPAN EXTENSION; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; DIETARY RESTRICTION; CELL-SURVIVAL; LONGEVITY; STRESS; SIR2; TRANSCRIPTION; NAD;
D O I：
10.1016/j.mad.2004.09.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent advances have suggested the existence of phylogenetically conserved pathways regulating ageing in eukaryotes. At least two of these "public" longevity-determining pathways appear to have been evolutionarily conserved from yeast through mammals. We have developed a high-throughput. genome-wide approach to identify a large fraction of the non-essential. single-gene deletion mutations that confer increased longevity in yeast. The identification and characterization of conserved genes that regulate the ageing process across eukaryotic species is likely to result in an improved understanding of the causes of human ageing and provide potential therapeutic targets for drug discovery. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：17 / 21
页数：5
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