Labelling of anilines, benzylamines and some N-heterocyclics using cycloocta-1,5-dienyliridium(I)-1,1,1,5,5,5-hexafluoro-pentan-2,4-dionate and isotopic hydrogen gas in DMF or DMA

被引：33

作者：

Garman, RN

Hickey, MJ

Kingston, LP

McAuley, B

Jones, JR

Lockley, WJS ^{[1
]}

Mather, AN

Wilkinson, DJ

机构：

[1] Univ Surrey, Dept Chem, Sch Biol & Mol Sci, Guildford GU2 7XH, Surrey, England

[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2005年 / 48卷 / 01期

关键词：

anilines; benzylamines; ortho-labelling; cycloocta-1,5-dienyliridium(I)1,1,1,5,5,5-hexafluoropentan-2,4-dionate; deuteration; CH-activation; isotope-exchange; COD.Ir.F(6)Acac;

D O I：

10.1002/jlcr.898

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A wide range of anilines, benzylamines and some N-heterocyclics can be ortho-deuterated at room temperature using deuterium gas and cycloocta-1,5-dienyliridiu-m(I)-1,1,1,5,5,5-hexafluoropentan-2,4-dionate in DMF or DMA. The method is applicable to labelling with tritium. Copyright (C) 2004 John Wiley Sons, Ltd.

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页码：75 / 84

页数：10

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