To be or notch to be

被引：10

作者：

Brenner, M ^{[1
]}

机构：

[1] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 11期

关键词：

D O I：

10.1038/81297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Constitutive activation of Notch signaling in hematopoietic cells establishes an immortalized hematopoietic stem cell population capable of developing into both myeloid and lymphoid lineages. This system will be useful in determining Notch-mediated mechanisms of hematopoietic differentiation (pages 1278–1281).

引用

页码：1210 / 1211

页数：2

共 10 条

[1] NOTCH SIGNALING [J].

ARTAVANISTSAKONAS, S ;

MATSUNO, K ;

FORTINI, ME .

SCIENCE, 1995, 268 (5208) :225-232

[2] MAKING A DIFFERENCE - THE ROLE OF CELL-CELL INTERACTIONS IN ESTABLISHING SEPARATE IDENTITIES FOR EQUIVALENT CELLS [J].

GREENWALD, I ;

RUBIN, GM .

CELL, 1992, 68 (02) :271-281

[3] Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells [J].

Jones, P ;

May, G ;

Healy, L ;

Brown, J ;

Hoyne, G ;

Delassus, S ;

Enver, T .

BLOOD, 1998, 92 (05) :1505-1511

[4] The LIN-12/Notch signaling pathway and its regulation [J].

Kimble, J ;

Simpson, P .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :333-361

[5] Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [J].

Pear, WS ;

Aster, JC ;

Scott, ML ;

Hasserjian, RP ;

Soffer, B ;

Sklar, J ;

Baltimore, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2283-2291

[6] Deficient T cell fate specification in mice with an induced inactivation of Notch1 [J].

Radtke, F ;

Wilson, A ;

Stark, G ;

Bauer, M ;

van Meerwijk, J ;

MacDonald, HR ;

Aguet, M .

IMMUNITY, 1999, 10 (05) :547-558

[7] Regulation of T cell fate by Notch [J].

Robey, E .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :283-295

[8] Notch in vertebrates [J].

Robey, E .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (04) :551-557

[9] Hox homeobox genes as regulators of normal and leukemic hematopoiesis [J].

Thorsteinsdottir, U ;

Sauvageau, G ;

Humphries, RK .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1997, 11 (06) :1221-+

[10] Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling [J].

Varnum-Finney, B ;

Xu, LW ;

Brashem-Stein, C ;

Nourigat, C ;

Flowers, D ;

Bakkour, S ;

Pear, WS ;

Bernstein, ID .

NATURE MEDICINE, 2000, 6 (11) :1278-1281

← 1 →