Electrochemically Enabled Double C-H Activation of Amides: Chemoselective Synthesis of Polycyclic Isoquinolinones

被引：64
作者：
Wang, Zi-Qiang [1 ]
Hou, Cheng [1 ]
Zhong, Yuan -Fang [1 ]
Lu, Yu-Xuan [1 ]
Mo, Zu-Yu [1 ]
Pan, Ying-Ming [1 ]
Tang, Hai-Tao [1 ]
机构：
[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Sch Chem & Pharmaceut Sci, Guilin 541004, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 24期
基金：
中国国家自然科学基金;
关键词：
BENZAMIDES; OXIDANT; METAL; ANNULATION; DISCOVERY; CATALYSIS; EFFICIENT; ACCESS;
D O I：
10.1021/acs.orglett.9b03682
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We developed an electrochemically enabled dehydrogenative annulation reaction of amides and alkynes for the synthesis of antitumor polycyclic isoquinolinones through a double C-H activation route. No external oxidant is required in this reaction, and electricity is used for Ru catalyst circulation. The most remarkable feature of this reaction is the effective improvement of product regioselectivity under mild electrolytic conditions in comparison with previously set strong oxidant conditions.
引用
收藏
页码：9841 / 9845
页数：5
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