Central memory T cells are the most effective precursors of resident memory T cells in human skin

被引:26
作者
Matos, Tiago R. [1 ,2 ,3 ]
Gehad, Ahmed [1 ]
Teague, Jessica E. [1 ]
Dyring-Andersen, Beatrice [1 ]
Benezeder, Theresa [1 ,4 ]
Dowlatshahi, Mitra [5 ]
Crouch, Jack [1 ]
Watanabe, Yoshinori [1 ]
O'Malley, John T. [1 ]
Kupper, Thomas S. [1 ]
Yang, Chao [1 ]
Watanabe, Rei [1 ,6 ]
Clark, Rachael A. [1 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA
[2] Univ Lisbon, Inst Med Mol, Fac Med, Lisbon, Portugal
[3] Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam, Netherlands
[4] Med Univ Graz, Dept Dermatol, Graz, Austria
[5] Columbia Univ, Dept Pathol & Cell Biol, Irving Med Ctr, New York, NY USA
[6] Osaka Univ, Grad Sch Med, Dept Dermatol, Course Integrated Med, Osaka, Japan
基金
奥地利科学基金会;
关键词
PROTECTIVE IMMUNITY; CHEMOKINES; SUBSETS;
D O I
10.1126/sciimmunol.abn1889
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The circulating precursor cells that give rise to human resident memory T cells (T-RM) are poorly characterized. We used an in vitro differentiation system and human skin-grafted mice to study T-RM generation from circulating human memory T cell subsets. In vitro T-RM differentiation was associated with functional changes, including enhanced IL-17A production and FOXP3 expression in CD4(+) T cells and granzyme B production in CD8(+) T cells, changes that mirrored the phenotype of T cells in healthy human skin. Effector memory T cells (T-EM) had the highest conversion rate to T-RM in vitro and in vivo, but central memory T cells (T-CM) persisted longer in the circulation, entered the skin in larger numbers, and generated increased numbers of T-RM. In summary, T-CM are highly efficient precursors of human skin T-RM, a feature that may underlie their known association with effective long-term immunity.
引用
收藏
页数:10
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