Therapeutics effects of inhaled magnesium sulfate combined with adrenergic beta-2 agonist on children with acute asthma: Systematic review and meta-analysis

被引:4
作者
Kassab, Manal [1 ,6 ]
Shdiefat, Doaa [2 ]
Hadoush, Hikmat [3 ]
Kanaan, Saddam [4 ,5 ]
机构
[1] Jordan Univ Sci & Technol JUST, Maternal & Child Hlth Dept, Fac Nursing, Irbid, Jordan
[2] Al Mafroq Hosp, Emergency Dept, MSN Maternal & Child Hlth Dept, Fac Nursing, Irbid, Jordan
[3] Jordan Univ Sci & Technol, Fac Appl Med Sci, Dept Rehabil Sci, POB 3030, Irbid 22110, Jordan
[4] Jordan Univ Sci & Technol, Dept Rehabil Sci, POB 3030, Irbid 22110, Jordan
[5] Jordan Univ Sci & Technol, Fac Appl Med Sci, POB 3030, Irbid 22110, Jordan
[6] Univ Technol Sydney UTS, Fac Hlth, Sydney, NSW, Australia
来源
JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES | 2022年 / 64卷
关键词
Magnesium sulfate; Asthma; Pediatrics; Adrenergic beta-agonist; Meta-analysis; EXACERBATIONS;
D O I
10.1016/j.pedn.2022.01.007
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
Aim: To review the evidence on the effectiveness of inhaled magnesium sulfate (MgSO4) combined with beta-2 (B2) agonist as compared to inhaled B2 agonist alone in treating pediatric patients with moderate to severe asthma attacks Methods: The search was conducted on five electronic databases namely the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, PubMed, Science Direct, and Google Scholar. Results: Eight trials were included in the review. All studies involved a total of 1585 children aged 2-17 years with moderate to severe asthma attacks. The risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials. Three studies that assessed the effect of inhaled MgSO4 as adjunctive therapy on vital signs revealed no effect of inhaled MgSO4 on vital signs (SMD -0.11, 95% CI 0.27-0.04, p = 0.16, I-2 = 68%). Two studies that assessed the effect of inhaled MgSO4 as adjunctive therapy on asthma severity score (ASS) revealed no effect of inhaled MgSO4 on ASS (SMD 0.22, 95% CI 0.01-0.44, Z = 2.01, p= 0.04, I-2 = 88%). Two studies that assessed the effect of inhaled MgSO4 as adjunctive therapy on peak expiratory flow rate (PEFR) revealed a large effect of B2 agonist alone on PEFR (SMD 2.02, 95% CI 0.83-3.2, p < 0.001, I-2 = 98%). Conclusion: This review does not support the use of inhaled MgSO4 as adjunctive therapy to B2 agonist for asthmatic children. (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码:E40 / E51
页数:12
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