Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease

被引：36

作者：

Bhounsule, Anisha S. ^{[1
]}

Bhatt, Lokesh Kumar ^{[1
]}

Prabhavalkar, Kedar S. ^{[1
]}

Oza, Manisha ^{[1
]}

机构：

[1] SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmacol, Bombay, Maharashtra, India

来源：

BRAIN RESEARCH BULLETIN | 2017年 / 132卷

关键词：

Alzheimer's disease; Cdk5; Deregulation; Amyloid precursor protein; Neurofibrillary tangles; AMYLOID PRECURSOR PROTEIN; A-BETA-PRODUCTION; CDK5; ACTIVITY; OXIDATIVE STRESS; NEUROFIBRILLARY TANGLES; S-NITROSYLATION; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL FISSION; CASCADE RELEVANCE; AXONAL-TRANSPORT;

D O I：

10.1016/j.brainresbull.2017.05.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is one of the most frequently encountered diseases in adults with progressive loss of memory and behavioral changes. Inspite of there being an intense research in the field of AD, only a few chemical entities exhibiting anti-AD activity make it through the clinical trials and it is thus need of an hour to develop new drugs or repurpose the existing ones for better management of Alzheimer's disease. Novel therapeutic targets can influence drug discovery in the field of AD. Cyclin Dependent Kinase 5 (Cdk5) which is a serine/threonine kinase can prove to be an upcoming beneficial target to be studied for treating AD. Cdk5 is important for development of CNS and neuron movements, however in AD pathological stimuli cause Cdk5 hyperactivation which eventually results in hyperphosphorylation of various substrates such as amyloid precursor protein, tau and many more. This review provides an insight on Cdk5 as a target for treatment of AD and discuss therapeutic candidates for targeting it.

引用

页码：28 / 38

页数：11

共 128 条

[1] Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid [J].

Ando, K ;

Iijima, K ;

Elliott, JI ;

Kirino, Y ;

Suzuki, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (43) :40353-40361

[2]

[Anonymous], BRAIN RES B

[3] Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles [J].

Augustinack, JC ;

Sanders, JL ;

Tsai, LH ;

Hyman, BT .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2002, 61 (06) :557-564

[4] The BRET technology and its application to screening assays [J].

Bacart, Johan ;

Corbel, Caroline ;

Jockers, Ralf ;

Bach, Stéphane ;

Couturier, Cyril .

Biotechnology Journal, 2008, 3 (03) :311-324

[5] Alzheimer Amyloid Peptide Aβ42 Regulates Gene Expression of Transcription and Growth Factors [J].

Barucker, Christian ;

Sommer, Anette ;

Beckmann, Georg ;

Eravci, Murat ;

Harmeier, Anja ;

Schipke, Carola G. ;

Brockschnieder, Damian ;

Dyrks, Thomas ;

Althoff, Veit ;

Fraser, Paul E. ;

Hazrati, Lili-Naz ;

St George-Hyslop, Peter ;

Breitner, John C. S. ;

Peters, Oliver ;

Multhaup, Gerhard .

JOURNAL OF ALZHEIMERS DISEASE, 2015, 44 (02) :613-624

[6] Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease [J].

Ben Aissa, Manel ;

Lee, Sue H. ;

Bennett, Brian M. ;

Thatcher, Gregory R. J. .

CURRENT MEDICINAL CHEMISTRY, 2016, 23 (24) :2770-2788

[7]

Borsello T, 2007, CURR PHARM DESIGN, V13, P1875

[8] Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts [J].

Boulahjar, Rajaa ;

Ouach, Aziz ;

Matteo, Chiurato ;

Bourg, Stephane ;

Ravache, Myriam ;

le Guevel, Remy ;

Marionneau, Severine ;

Oullier, Thibauld ;

Lozach, Olivier ;

Meijer, Laurent ;

Guguen-Guillouzo, Christiane ;

Lazar, Said ;

Akssira, Mohamed ;

Troin, Yves ;

Guillaumet, Gerald ;

Routier, Sylvain .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (22) :9589-9606

[9] The relationship of tamoxifen with dementia, depression, and dependence in activities of daily living in elderly nursing home residents [J].

Breuer, B ;

Anderson, R .

WOMEN & HEALTH, 2000, 31 (01) :71-85

[10] Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease [J].

Calkins, Marcus J. ;

Manczak, Maria ;

Mao, Peizhong ;

Shirendeb, Ulziibat ;

Reddy, P. Hemachandra .

HUMAN MOLECULAR GENETICS, 2011, 20 (23) :4515-4529

← 1 2 3 4 5 6 7 8 9 10 →