Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota

被引:23
|
作者
Guo, Jianying [1 ]
Ma, Baochen [2 ]
Wang, Zixu [1 ]
Chen, Yaoxing [1 ]
Tian, Wenli [3 ]
Dong, Yulan [1 ]
机构
[1] China Agr Univ, Coll Vet Med, Key Lab Precis Nutr & Food Qual, Minist Educ, Beijing 100193, Peoples R China
[2] China Anim Husb Grp, Beijing 100070, Peoples R China
[3] Chinese Acad Agr Sci, Inst Apicultural Res, Beijing 100093, Peoples R China
基金
中国国家自然科学基金;
关键词
royal jelly; inflammatory bowel disease; colitis; intestinal mucosal barrier; gut microbiota; APIS-MELLIFERA; ACID; DISEASE; MECHANISMS; PROTEINS; INNATE; IBD;
D O I
10.3390/nu14102069
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Royal jelly (RJ) is a natural bee product that contains a variety of biologically active ingredients and has antitumor, antiallergic, antibacterial and immune-regulating effects. Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that can cause abdominal pain and diarrhea. With this study, we aimed to explore the protective effect of RJ on DSS-induced colitis in mice. The physiochemical parameters (water, protein, 10-hydroxy-2-decenoic acid, total sugar, starch, ash and acidity) of the RJ samples used in this study met the requirements of the international and Chinese national standards. Treatment with RJ improved symptoms and colonic cell apoptosis and decreased intestinal permeability by increasing the expression of tight-junction protein, goblet cells and their secretion mucin, MUC2, in DSS-induced ulcerative colitis mice. RJ also reduced the expression of proinflammatory cytokine IL-6 and increased the expression of anti-inflammatory cytokine IL-10 and sIgA. DSS resulted in an increase in the relative abundance of Parabacteroides, Erysipelotrichaceae, Proteobacteria (Gammaproteobacteria, Enterobacteriales and Enterobacteriaceae) and Escherichia Shigella in the colon and a decrease in the relative abundance of Muribaculum. In the RJ treatment group, the relative abundance of the above intestinal flora was improved by treatment with 2.0 g/kg RJ. These results suggested that RJ alleviated DSS-induced colitis by improving the colonic mucosal barrier.
引用
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页数:15
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