Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis

被引：107
作者：
Spruck, CH
de Miguel, MP
Smith, APL
Ryan, A
Stein, P
Schultz, RM
Lincoln, AJ
Donovan, PJ
Reed, SI
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[3] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
[4] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
来源：
SCIENCE | 2003年 / 300卷 / 5619期
关键词：
D O I：
10.1126/science.1084149
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We generated mice lacking Cks2, one of two mammalian homologs of the yeast Cdk1-binding proteins, Suc1 and Cks1, and found them to be viable but sterile in both sexes. Sterility is due to failure of both male and female germ cells to progress past the first meiotic metaphase. The chromosomal events up through the end of prophase I are normal in both CKS2(-/-) males and females, suggesting that the phenotype is due directly to failure to enter anaphase and not a consequence of a checkpoint-mediated metaphase I arrest.
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页码：647 / 650
页数：4
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