Cytotoxic and anti-inflammatory activities of secondary metabolites from Ophiorrhiza baviensis growing in Thua Thien Hue, Vietnam

被引：7

作者：

Le Canh Viet Cuong ^{[1
]}

Le Tuan Anh ^{[1
,2
]}

Ton That Huu Dat ^{[1
]}

Tran Thi Phuong Anh ^{[2
]}

Le Quynh Lien ^{[3
]}

Kim, Young Ho ^{[4
]}

Hoang Le Tuan Anh ^{[1
,2
]}

机构：

[1] VAST, Mientrung Inst Sci Res, Hue City, Vietnam

[2] VAST, Grad Univ Sci & Technol, Hanoi, Vietnam

[3] VAST, Dept Int Cooperat, Hanoi, Vietnam

[4] Chungnam Natl Univ, Coll Pharm, Daejeon, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

关键词：

Ophiorrhiza baviensis; triterpene; anti-inflammatory activity; cytotoxic activity; CHEMICAL-CONSTITUENTS; TRITERPENE ACIDS; INDOLE ALKALOIDS; LEAVES; URSANE; PLANT; BARK;

D O I：

10.1080/14786419.2019.1693564

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new ursane-type triterpene, 3 beta,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2-9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2-5 were found for the first time from the genus Ophiorrhiza, while compounds 6-9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR (H-1-NMR, C-13-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.

引用

页码：4218 / 4224

页数：7

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