An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts

被引：120

作者：

Cho, Sung-Yup ^{[1
]}

Kang, Wonyoung ^{[1
]}

Han, Jee Yun ^{[1
]}

Min, Seoyeon ^{[1
]}

Kang, Jinjoo ^{[1
]}

Lee, Ahra ^{[1
]}

Kwon, Jee Young ^{[1
,2
]}

Lee, Charles ^{[1
,2
]}

Park, Hansoo ^{[1
,2
]}

机构：

[1] Ewha Womans Univ, Dept Life Sci, Seoul 120750, South Korea

[2] Jackson Lab Genom Med, Farmington, CT 06032 USA

来源：

MOLECULES AND CELLS | 2016年 / 39卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cancer drug development; cancer genomics; patient-derived xenografts; precision medicine; BREAST-CANCER; TUMOR XENOGRAFTS; MOLECULAR CHARACTERIZATION; ORTHOTOPIC XENOGRAFTS; PANCREATIC-CANCER; NAB-PACLITAXEL; LUNG CANCERS; MOUSE MODELS; IN-VITRO; GLIOBLASTOMA;

D O I：

10.14348/molcells.2016.2350

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients' tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine.

引用

页码：77 / 86

页数：10

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