Current Immunotherapies for Glioblastoma Multiforme

被引：100

作者：

Huang, Boyuan ^{[1
]}

Li, Xuesong ^{[2
]}

Li, Yuntao ^{[3
]}

Zhang, Jin ^{[4
]}

Zong, Zhitao ^{[5
]}

Zhang, Hongbo ^{[2
,3
,5
]}

机构：

[1] Beijing Elect Power Hosp, Dept Neurosurg, Beijing, Peoples R China

[2] Guangzhou Med Univ, Huizhou Peoples Hosp 3, Dept Neurosurg, Huizhou, Peoples R China

[3] Southern Med Univ, Dept Neurosurg,Zhujiang Hosp, Natl Key Clin Specialty,Engn Technol Res Ctr, Educ Minist China,Guangdong Prov Key Lab Brain Fu, Guangzhou, Peoples R China

[4] Jinan Univ, Affiliated Hosp 1, Dept Neurosurg, Guangzhou, Peoples R China

[5] Jiujiang Hosp Tradit Chinese Med, Dept Neurosurg, Jiujiang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 11卷

关键词：

immunotherapy; glioblastoma multiforme; glioma; vaccines; checkpoint inhibitors;

D O I：

10.3389/fimmu.2020.603911

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor found in the central nervous system. Currently, standard treatments in the clinic include maximal safe surgical resection, radiation, and chemotherapy and are mostly limited by low therapeutic efficiency correlated with poor prognosis. Immunotherapy, which predominantly focuses on peptide vaccines, dendritic cell vaccines, chimeric antigen receptor T cells, checkpoint inhibitor therapy, and oncolytic virotherapy, have achieved some promising results in both preclinical and clinical trials. The future of immune therapy for GBM requires an integrated effort with rational combinations of vaccine therapy, cell therapy, and radio- and chemotherapy as well as molecule therapy targeting the tumor microenvironment.

引用

页数：12

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