Diffuse Alveolar Hemorrhage following Itraconazole Injection

被引：4

作者：

Izumikawa, Koichi ^{[1
]}

Nakano, Ken ^{[1
]}

Kurihara, Shintaro ^{[1
]}

Imamura, Yoshifumi ^{[1
]}

Yamamoto, Kazuko ^{[1
]}

Miyazaki, Taiga ^{[1
]}

Sakamoto, Noriho ^{[1
]}

Seki, Masafumi ^{[1
]}

Ishimatsu, Yuji ^{[1
]}

Kakeya, Hiroshi ^{[1
]}

Yamamoto, Yoshihiro ^{[1
]}

Yanagihara, Katsunori ^{[2
]}

Tsuchiya, Tomoshi ^{[3
]}

Yamasaki, Naoya ^{[3
]}

Tagawa, Tsutomu ^{[3
]}

Mukae, Hiroshi ^{[1
]}

Nagayasu, Takeshi ^{[3
]}

Kohno, Shigeru ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 852, Japan

[2] Nagasaki Univ, Sch Med, Dept Lab Med, Nagasaki 852, Japan

[3] Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 852, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 05期

关键词：

diffuse alveolar hemorrhage; intravenous itraconazole; PMX; LYMPHOCYTE-TRANSFORMATION TEST; RESPIRATORY-DISTRESS-SYNDROME; B-IMMOBILIZED FIBER; DIAGNOSIS; SENSITIVITY; DISEASES;

D O I：

10.2169/internalmedicine.49.2735

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse alveolar hemorrhage (DAH) syndrome is potentially fatal. We encountered a nearly fatal case of DAH possibly due to intravenous itraconazole (ITCZ). A 53-year-old man with chronic pulmonary aspergillosis underwent pneumonectomy of the left lung 15 days prior to the onset of DAH, which was confirmed by bronchoalveloar lavage. The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test. The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy.

引用

页码：497 / 500

页数：4

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