An Efficient Approach to Access 2,2-Diarylanilines via Visible-Light-Promoted Decarboxylative Cross-Coupling Reactions

被引：11

作者：

Luo, Cong ^{[1
]}

Zhou, Tongyao ^{[2
]}

Wang, Wei ^{[2
]}

Han, Pan ^{[1
]}

Jing, Linhai ^{[1
]}

机构：

[1] China West Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, 1 Shi Da Rd, Nanchong 637009, Peoples R China

[2] Wuhan Inst Technol, Pharmaceut Res Inst, 206,Guanggu 1st Rd, Wuhan 430205, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Decarboxylative; 2; 2-Diarylanilines; Glycines; para-Quinone methides; photoredox catalysis; PARA-QUINONE METHIDES; 1,6-CONJUGATE ADDITION; SPIROCYCLOPROPANATION REACTION; ASYMMETRIC-SYNTHESIS; 4+2 CYCLOADDITION; SULFONIUM SALTS; MOLECULAR-BASIS; PHOTOREDOX; ACIDS; REARRANGEMENT;

D O I：

10.1002/ajoc.202100458

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward protocol for the visible-light-promoted decarboxylative 1,6-conjugate addition of N-aryl glycines to para-quinone methides under transition-metal-free conditions is disclosed. This method provides scalable and efficient access to 2,2-diarylanilines with biological and pharmacologic potential in good to excellent yields (39 examples, up to 97% yield). The synthetic utility of this work has been illustrated in the efficient synthesis of 3-substituted indoline.

引用

页码：2342 / 2346

页数：5

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