The utility of sputum eosinophils and exhaled nitric oxide for monitoring asthma control with special attention to childhood asthma

被引:10
|
作者
Garcia-Marcos, L. [1 ,2 ,3 ]
Brand, P. L. [4 ,5 ]
机构
[1] Univ Murcia, Virgen Arrixaca Univ Childrens Hosp, Paediat Resp Unit, Murcia, Spain
[2] Univ Murcia, Virgen Arrixaca Univ Childrens Hosp, Allergy Unit, Murcia, Spain
[3] CIBER Epidemiol & Publ Hlth CIBERSP, Murcia, Spain
[4] Univ Groningen, Univ Med Ctr Groningen, Postgrad Med Sch, NL-9713 AV Groningen, Netherlands
[5] Isala Klin, Princess Amalia Childrens Clin, Zwolle, Netherlands
关键词
Asthma treatment; Induced sputum; Children; AIRWAY INFLAMMATION; CATIONIC PROTEIN; INHALED CORTICOSTEROIDS; CELL COUNTS; MARKERS; RESPONSIVENESS; BUDESONIDE; SALMETEROL; PREDICTORS; REDUCTION;
D O I
10.1016/j.aller.2009.10.006
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The monitoring of sputum eosinophils has received certain attention as a tool for improving asthma management both in children and in adults. The present paper reviews the technique and also the usefulness of induced sputum in the diagnosis and assessment of asthma, together with its ability to predict the response to treatment and to anticipate asthma exacerbations. Special attention is addressed to childhood asthma. The authors conclude that due to cost-effectiveness reasons derived from high labour costs, together with the unpleasantness of the technique and the failure to obtain adequate samples in a non-negligible percentage of children, this technique should be only used for research purposes. (C) 2009 SEICAF Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码:41 / 46
页数:6
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