Alternative Activation of Macrophages: Mechanism and Functions

被引：3203
作者：
Gordon, Siamon [1 ]
Martinez, Fernando O. [1 ]
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
IMMUNITY | 2010年 / 32卷 / 05期
关键词：
ANTIGEN-PRESENTING CELLS; RECEPTOR-ACTIVITY; SUPPRESSOR-CELLS; VIRAL-INFECTION; SHIP REPRESSES; IN-VITRO; IL-13; INFLAMMATION; EXPRESSION; POLARIZATION;
D O I：
10.1016/j.immuni.2010.05.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
引用
收藏
页码：593 / 604
页数：12
相关论文
共 113 条
  • [11] Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways
    Cole, Leah E.
    Santiago, Araceli
    Barry, Eileen
    Kang, Tae Jin
    Shirey, Kari Ann
    Roberts, Zachary J.
    Elkins, Karen L.
    Cross, Alan S.
    Vogel, Stefanie N.
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 180 (10) : 6885 - 6891
  • [12] Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages
    Cole, Leah E.
    Shirey, Kari Ann
    Barry, Eileen
    Santiago, Araceli
    Rallabhandi, Prasad
    Elkins, Karen L.
    Puche, Adam C.
    Michalek, Suzanne M.
    Vogel, Stefanie N.
    [J]. INFECTION AND IMMUNITY, 2007, 75 (08) : 4127 - 4137
  • [13] The phenotype of murine wound macrophages
    Daley, Jean M.
    Brancato, Samielle K.
    Thomay, Alan A.
    Reichner, Jonathan S.
    Albina, Jorge E.
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2010, 87 (01) : 59 - 67
  • [14] The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
    Delgoffe, Greg M.
    Kole, Thomas P.
    Zheng, Yan
    Zarek, Paul E.
    Matthews, Krystal L.
    Xiao, Bo
    Worley, Paul F.
    Kozma, Sara C.
    Powell, Jonathan D.
    [J]. IMMUNITY, 2009, 30 (06) : 832 - 844
  • [15] CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
    DeNardo, David G.
    Barreto, Jairo B.
    Andreu, Pauline
    Vasquez, Lesley
    Tawfik, David
    Kolhatkar, Nikita
    Coussens, Lisa M.
    [J]. CANCER CELL, 2009, 16 (02) : 91 - 102
  • [16] Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling
    Dickensheets, H.
    Vazquez, N.
    Sheikh, F.
    Gingras, S.
    Murray, P. J.
    Ryan, J. J.
    Donnelly, R. P.
    [J]. GENES AND IMMUNITY, 2007, 8 (01) : 21 - 27
  • [17] INTERLEUKIN-13 ALTERS THE ACTIVATION STATE OF MURINE MACROPHAGES IN-VITRO - COMPARISON WITH INTERLEUKIN-4 AND INTERFERON-GAMMA
    DOYLE, AG
    HERBEIN, G
    MONTANER, LJ
    MINTY, AJ
    CAPUT, D
    FERRARA, P
    GORDON, S
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (06) : 1441 - 1445
  • [18] Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    El Kasmi, Karim C.
    Qualls, Joseph E.
    Pesce, John T.
    Smith, Amber M.
    Thompson, Robert W.
    Henao-Tamayo, Marcela
    Basaraba, Randall J.
    Koenig, Till
    Schleicher, Ulrike
    Koo, Mi-Sun
    Kaplan, Gilla
    Fitzgerald, Katherine A.
    Tuomanen, Elaine I.
    Orme, Ian M.
    Kanneganti, Thirumala-Devi
    Bogdan, Christian
    Wynn, Thomas A.
    Murray, Peter J.
    [J]. NATURE IMMUNOLOGY, 2008, 9 (12) : 1399 - 1406
  • [19] Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Fallon, PG
    Ballantyne, SJ
    Mangan, NE
    Barlow, JL
    Dasvarma, A
    Hewett, DR
    McIlgorm, A
    Jolin, HE
    McKenzie, ANJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (04) : 1105 - 1116
  • [20] Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
    Fernandez-Boyanapalli, Ruby F.
    Frasch, S. Courtney
    McPhillips, Kathleen
    Vandivier, R. William
    Harry, Brian L.
    Riches, David W. H.
    Henson, Peter M.
    Bratton, Donna L.
    [J]. BLOOD, 2009, 113 (09) : 2047 - 2055
12345678910