Alternative Activation of Macrophages: Mechanism and Functions

被引：3287

作者：

Gordon, Siamon ^{[1
]}

Martinez, Fernando O. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

IMMUNITY | 2010年 / 32卷 / 05期

关键词：

ANTIGEN-PRESENTING CELLS; RECEPTOR-ACTIVITY; SUPPRESSOR-CELLS; VIRAL-INFECTION; SHIP REPRESSES; IN-VITRO; IL-13; INFLAMMATION; EXPRESSION; POLARIZATION;

D O I：

10.1016/j.immuni.2010.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.

引用

页码：593 / 604

页数：12

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