Proton exchange kinetics in [d(ACGTATACGT)]2-echinomycin and [d(ACGTTAACGT)]2-echinomycin complexes

被引：1

作者：

Park, JY ^{[1
]}

Lee, JH ^{[1
]}

Choi, BS ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

FEBS LETTERS | 1998年 / 426卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

echinomycin; nuclear magnetic resonance; DNA complex; proton exchange;

D O I：

10.1016/S0014-5793(98)00366-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on imino proton exchange catalysis, base-pair lifetimes and apparent dissociation constants are reported on the complexes formed by bisintercalation of echinomycin at the CpG steps of the d(ACGTATACGT)(2) and d(ACGTTAACGT)(2) duplexes. The lifetimes of the four central A.T base pairs between two echinomycin binding sites are much shorter than in the free duplexes. The destabilization of base pairs adjacent to the binding sites is propagated one additional base pair away from the binding site. (C) 1998 Federation of European Biochemical Societies.

引用

页码：325 / 330

页数：6

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