Zeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa

被引：15

作者：

Ulusoy, Seyhan ^{[1
]}

B Akalin, Ramadan ^{[2
]}

cevikbas, Halime ^{[1
]}

Berisha, Avni ^{[3
,4
]}

Oral, Ayhan ^{[5
]}

Bosgelmez-Tinaz, Gulgun ^{[6
]}

机构：

[1] Suleyman Demirel Univ, Dept Biol, TR-32260 Isparta, Turkey

[2] Namik Kemal Univ, Vocat Sch Hlth Serv, TR-59030 Tekirdag, Turkey

[3] Univ Prishtina, Fac Nat & Math Sci, Dept Chem, Prishtina 10000, Kosovo

[4] NanoAlb Unit Albanian Nanosci & Nanotechnol, Mat Sci Nanochem Res Grp, Tirana 1000, Albania

[5] Onsekiz Mart Univ, Dept Chem, TR-18100 Canakkale, Turkey

[6] Marmara Univ, Dept Basic Pharm Sci, Fac Pharm, TR-34854 Istanbul, Turkey

来源：

FUTURE MICROBIOLOGY | 2022年 / 17卷 / 11期

关键词：

biofilms; modeling; Pseudomonas aeruginosa; quorum sensing; QUORUM SENSING INHIBITORS; BIOFILM FORMATION; ESSENTIAL OILS; GENES; DERIVATIVES; ADSORPTION; EXPRESSION; VIRULENCE; ENZYME; STEEL;

D O I：

10.2217/fmb-2021-0174

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections.

引用

页码：861 / 871

页数：11

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