3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi

被引：87

作者：

Schwarz, M

Köpcke, B

Weber, RWS

Sterner, O

Anke, H

机构：

[1] IBWF eV, D-67663 Kaiserslautern, Germany

[2] Univ Kaiserslautern, Dept Biotechnol, D-67663 Kaiserslautern, Germany

[3] Lund Univ, Dept Bioorgan Chem, S-22100 Lund, Sweden

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 15期

关键词：

Diaporthe phaseolorum; Phomopsis phaseoli; Melanconis stilbostoma; Melanconium betulinum; Meloidogyne incognita; endophyte; nematicidal activity; 3-Hydroxypropionic acid;

D O I：

10.1016/j.phytochem.2004.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3-Hydroxypropionic acid was isolated by bioactivity-guided fractionation of extracts obtained from submerged cultures of several endophytic fungi isolated from above-ground plant organs. This compound showed selective nematicidal activity against the plant-parasitic nematode Meloidogyne incognita with LD50 values of 12.5-15 mug/ml. Activity against the saprophytic Caenorhabditis elegans was fivefold lower. No antimicrobial, cytotoxic or phytotoxic effects were observed. Propionic acid and D- and L-lactic acids were not active against either nematode species. Based on morphological features and ITS, 18S and 28S rDNA analyses, the producing strains were identified as Phomopsis phaseoli isolated from the leaf of a tropical tree, and four strains of Melanconium betulinum isolated from twigs of Betula pendula and B. pubescens in Germany. This is the first report of 3-hydroxypropionic acid in fungi, and of the nematicidal activity of this metabolite. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2239 / 2245

页数：7

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