Fabrication of H2O2-driven nanoreactors for innovative cancer treatments

被引：58

作者：

Dong, Ziliang ^{[1
]}

Yang, Zhijuan ^{[1
]}

Hao, Yu ^{[1
]}

Feng, Liangzhu ^{[1
]}

机构：

[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

来源：

NANOSCALE | 2019年 / 11卷 / 35期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

IMMUNE-CHECKPOINT BLOCKADE; EFFICIENT PHOTODYNAMIC THERAPY; SOLID TUMOR MICROENVIRONMENT; OXIDATIVE STRESS; FENTON REACTION; ALBUMIN-MNO2; NANOPARTICLES; HYDROGEN-PEROXIDE; HIGHLY EFFICIENT; ROS STRESS; IN-VIVO;

D O I：

10.1039/c9nr04418c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The increased production of hydrogen peroxide (H2O2) is a typical feature of cancerous cells. This feature is closely associated with elevated oxidative stress inside solid tumour microenvironments, which thus impairs either the growth of cancer cells or their sensitivity to many cancer therapeutics. To date, numerous innovative strategies that target tumour H2O2 have been designed for effective cancer treatment. More recently, with the rapid advancement of nanomedicine, several nanoreactors, which are highly efficient in converting endogenous H2O2 to more toxic reactive oxygen species, promoting in situ H2O2, or decomposing endogenous H2O2 to molecular oxygen for tumour hypoxia attenuation, have been designed and attempted for effective cancer treatment. This review focuses on the latest progress of such innovative H2O2-driven nanoreactor-mediated cancer treatments. Afterwards, future perspectives on the development of tumour H2O2-driven nanoreactor-mediated cancer treatments and their potential clinical translations will be discussed.

引用

页码：16164 / 16186

页数：23

共 177 条

[1] New photosensitizers for photodynamic therapy [J].

Abrahamse, Heidi ;

Hamblin, Michael R. .

BIOCHEMICAL JOURNAL, 2016, 473 :347-364

[2] Oncologic photodynamic therapy photosensitizers: A clinical review [J].

Allison, Ron R. ;

Sibata, Claudio H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75

[3] Boosting doxorubicin-induced immunogenic cell death by using tumor microenvironment modulating nanoparticles [J].

Amini, Mohammad Ali ;

Abbasi, Azhar ;

Cai, Ping ;

Lip, Hoyin ;

Li, Jason ;

Gordijo, Claudia ;

Zhang, Li ;

Rauth, Michael ;

Wu, Xiao Yu .

CANCER RESEARCH, 2018, 78 (13)

[4]

[Anonymous], ADV MAT

[5]

[Anonymous], JNCI J NATL CANC I

[6] A Facile Ion-Doping Strategy To Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics [J].

Bai, Jing ;

Jia, Xiaodan ;

Zhen, Wenyao ;

Cheng, Wenlong ;

Jiang, Xiue .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (01) :106-109

[7] Principles of nanoparticle design for overcoming biological barriers to drug delivery [J].

Blanco, Elvin ;

Shen, Haifa ;

Ferrari, Mauro .

NATURE BIOTECHNOLOGY, 2015, 33 (09) :941-951

[8]

Bodey B, 2000, ANTICANCER RES, V20, P2665

[9] Exploiting tumour hypoxia in cancer treatment [J].

Brown, JM ;

William, WR .

NATURE REVIEWS CANCER, 2004, 4 (06) :437-447

[10]

Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/nnano.2011.166, 10.1038/NNANO.2011.166]

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