Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy

被引：26

作者：

Balbi, Massimiliano ^{[1
]}

Donadon, Valter ^{[1
]}

Ghersetti, Michela ^{[1
]}

Grazioli, Silvia ^{[1
]}

Della Valentina, Giovanni ^{[1
]}

Gardenal, Rita ^{[1
]}

Dal Mas, Maria ^{[1
]}

Casarin, Pietro ^{[1
]}

Zanette, Giorgio ^{[2
]}

Miranda, Cesare ^{[2
]}

Cimarosti, Paolo ^{[3
]}

机构：

[1] Pordenone Hosp, Dept Med, I-33170 Pordenone, Italy

[2] Pordenone Hosp, Diabet Clin, I-33170 Pordenone, Italy

[3] Pordenone Hosp, Community Addict Serv, I-33170 Pordenone, Italy

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2010年 / 7卷 / 04期

关键词：

Hepatocellular carcinoma; Type 2 diabetes mellitus; HCV infections; alcohol abuse; CHRONIC LIVER-DISEASE; OXIDATIVE STRESS; VIRAL-HEPATITIS; UNITED-STATES; CANCER; COMPLICATIONS; CONSUMPTION; POPULATION; MORTALITY; COHORT;

D O I：

10.3390/ijerph7041366

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.

引用

页码：1366 / 1378

页数：13

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