Glycoprotein A is the immunodominant antigen of Pneumocystis carinii in mice following immunization

被引：15

作者：

Gigliotti, F

McCool, T

机构：

[1] University of Rochester, Medical Center, Rochester, NY 14642

来源：

PARASITOLOGY RESEARCH | 1996年 / 82卷 / 01期

关键词：

D O I：

10.1007/s004360050075

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A rapid and simple dual enzyme-linked immunosorbent assay was developed to quantitate the relative frequency of monoclonal antibodies produced against Pneumocystis carinii glycoprotein A (gpA) or other antigens of P. carinii after immunization with whole organisms. In BALB/cj mice, P. carinii gpA was clearly the immunodominant antigen, with a quarter of all hybridomas secreting antibody directed against this molecule.

引用

页码：90 / 91

页数：2

共 4 条

[1] Gigliotti F, Host species-specific antigenic variation of a mannosylated surface glycoprotein of Pneumocystis carinii, J Infect Dis, 165, pp. 329-336, (1992)
[2] Gigliotti F, Stokes DC, Cheatham AB, Davis DS, Hughes WT, Development of murine monoclonal antibodies to Pneumocystis carinii, J Infect Dis, 14, pp. 315-322, (1986)
[3] Gigliotti F, Ballou LR, Hughes WT, Mosley BD, Purification and initial characterization of a ferret Pneumocystis carinii surface antigen, J Infect Dis, 158, pp. 848-854, (1988)
[4] Peglow SL, Smulian AG, Linke MJ, Pogue CL, Nurre S, Crisler J, Phair J, Gold JWM, Armstrong D, Walzer PD, Serologic responses to Pneumocystis carinii antigens in health and disease, J Infect Dis, 161, pp. 296-306, (1990)

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