The Hunt for Natural Skin Whitening Agents

被引：195

作者：

Smit, Nico ^{[1
]}

Vicanova, Jana ^{[2
]}

Pavel, Stan ^{[3
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Clin Chem, NL-2300 RC Leiden, Netherlands

[2] DermData, Prague, Czech Republic

[3] Leiden Univ, Med Ctr, Dept Dermatol, NL-2300 RC Leiden, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 12期

关键词：

whitening; tyrosinase inhibitors; natural agents; cosmetics; ULTRAVIOLET-INDUCED PIGMENTATION; TYROSINASE-INHIBITORY-ACTIVITY; MELANOMA B16 CELLS; SOPHORA-FLAVESCENS; HUMAN MELANOCYTES; ANTI-TYROSINASE; DOWN-REGULATION; IN-VITRO; ARTOCARPUS-HETEROPHYLLUS; TREAT HYPERPIGMENTATION;

D O I：

10.3390/ijms10125326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Whitening agents act at various levels of melanin production in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme in melanogenesis. Others inhibit the maturation of this enzyme or the transport of pigment granules (melanosomes) from melanocytes to surrounding keratinocytes. In this review we present an overview of (natural) whitening products that may decrease skin pigmentation by their interference with the pigmentary processes.

引用

页码：5326 / 5349

页数：24

共 127 条

[1]

Adhikari A., 2008, International Journal of Cosmetic Science, V30, P353, DOI 10.1111/j.1468-2494.2008.00463.x

[2] Wnt/β-catenin signaling [J].

Akiyama, T .

CYTOKINE & GROWTH FACTOR REVIEWS, 2000, 11 (04) :273-282

[3]

ARUNG ET, 2009, NAT MED TOKYO, V63, P473

[4] Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship [J].

Azhar-ul-Haq ;

Malik, A ;

Khan, MTH ;

Anwar-ul-Haq ;

Khan, SB ;

Ahmad, A ;

Choudhary, MI .

PHYTOMEDICINE, 2006, 13 (04) :255-260

[5] Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki [J].

Baek, Yoon Su ;

Ryu, Young Bae ;

Curtis-Long, Marcus J. ;

Ha, Tae Joung ;

Rengasamy, Rajesh ;

Yang, Min Suk ;

Park, Ki Hun .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (01) :35-41

[6] Environmentally friendly LC for the simultaneous determination of ascorbic acid and its derivatives in skin-whitening cosmetics [J].

Balaguer, Angel ;

Chisvert, Alberto ;

Salvador, Arnparo .

JOURNAL OF SEPARATION SCIENCE, 2008, 31 (02) :229-236

[7] Preliminary screening of some tropical plants for anti-tyrosinase activity [J].

Baurin, N ;

Arnoult, E ;

Scior, T ;

Do, QT ;

Bernard, P .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 82 (2-3) :155-158

[8] RETRACTED: Tissue culture of some lichens and screening of their antioxidant, antityrosinase and antibacterial properties (Retracted article. See vol 22, pg 708, 2008) [J].

Behera, B. C. ;

Verma, Neeraj ;

Sonone, Anjali ;

Makhija, Urmila .

PHYTOTHERAPY RESEARCH, 2007, 21 (12) :1159-1170

[9]

Behera Bhaskar C., 2006, Journal of Herbal Pharmacotherapy, V6, P55, DOI [10.1300/J157v06n01_06, 10.1080/J157v06n01_06]

[10]

Brenner Michaela, 2008, Drug Discov Today Dis Mech, V5, pe189, DOI 10.1016/j.ddmec.2008.02.001

← 1 2 3 4 5 6 7 8 9 10 →