Fucoidan antagonizes diet-induced obesity and inflammation in mice

被引：12

作者：

Wang, Lei ^{[1
]}

Zhang, Kun ^{[1
]}

Ding, Xin ^{[1
]}

Wang, Yan ^{[1
]}

Bai, Hui ^{[1
]}

Yang, Qing ^{[1
]}

Ben, Jingjing ^{[1
]}

Zhang, Hanwen ^{[1
]}

Li, Xiaoyu ^{[1
]}

Chen, Qi ^{[1
]}

Zhu, Xudong ^{[1
]}

机构：

[1] Nanjing Med Univ, CollaborativeInnovat Ctr Cardiovasc Dis Translat, Key Lab Targeted Intervent Cardiovasc Dis, 101 Longmian Rd, Nanjing 211166, Jiangsu, Peoples R China

来源：

JOURNAL OF BIOMEDICAL RESEARCH | 2021年 / 35卷 / 03期

基金：

中国国家自然科学基金;

关键词：

obesity; adipose tissue; fucoidan; inflammation; ADIPOSE-TISSUE; INSULIN-RESISTANCE; DYSFUNCTION; EXPRESSION;

D O I：

10.7555/JBR.34.20200153

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Obesity is an escalating global pandemic posing a serious threat to human health. The intervention therapy using weight-reducing drugs, accompanied by lifestyle modification, is a strategy for the treatment of obesity. In the present study, we explored the role of fucoidan, a seaweed compound, on high-fat diet (HFD)-induced obesity in mice. We found that fucoidan treatment significantly reduced the body fat and caused redistribution of visceral and subcutaneous fat in HFD-fed mice. Meanwhile, fucoidan treatment inhibited adipocyte hypertrophy and inflammation in adipose tissue. Collectively, these results suggest that fucoidan may be a promising treatment for obesity and obesity-induced complications.

引用

页码：197 / 205

页数：9

共 37 条

[1] Health Effects of Overweight and Obesity in 195 Countries over 25 Years [J].

Afshin, Ashkan ;

Forouzanfar, Mohammad H. ;

Reitsma, Marissa B. ;

Sur, Patrick ;

Estep, Kara ;

Lee, Alex ;

Marczak, Laurie ;

Mokdad, Ali H. ;

Moradi-Lakeh, Maziar ;

Naghavi, Mohsen ;

Salama, Joseph S. ;

Vos, Theo ;

Abate, Kalkidan H. ;

Abbafati, Cristiana ;

Ahmed, Muktar B. ;

Al-Aly, Ziyad ;

Alkerwi, Ala'a ;

Al-Raddadi, Rajaa ;

Amare, Azmeraw T. ;

Amberbir, Alemayehu ;

Amegah, Adeladza K. ;

Amini, Erfan ;

Amrock, Stephen M. ;

Anjana, Ranjit M. ;

Arnlov, Johan ;

Asayesh, Hamid ;

Banerjee, Amitava ;

Barac, Aleksandra ;

Baye, Estifanos ;

Bennett, Derrick A. ;

Beyene, Addisu S. ;

Biadgilign, Sibhatu ;

Biryukov, Stan ;

Bjertness, Espen ;

Boneya, Dube J. ;

Campos-Nonato, Ismael ;

Carrero, Juan J. ;

Cecilio, Pedro ;

Cercy, Kelly ;

Ciobanu, Liliana G. ;

Cornaby, Leslie ;

Damtew, Solomon A. ;

Dandona, Lalit ;

Dandona, Rakhi ;

Dharmaratne, Samath D. ;

Duncan, Bruce B. ;

Eshrati, Babak ;

Esteghamati, Alireza ;

Feigin, Valery L. ;

Fernandes, Joao C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (01) :13-27

[2] Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1 [J].

Aleissa, Mohammed S. ;

Alkahtani, Saad ;

Abd Eldaim, Mabrouk Attia ;

Ahmed, Ali Meawad ;

Bungau, Simona G. ;

Almutairi, Bader ;

Bin-Jumah, May ;

AlKahtane, Abdullah A. ;

Alyousif, Mohamed S. ;

Abdel-Daim, Mohamed M. .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020

[3]

[Anonymous], 2016, The lancet, V387, P1377, DOI [10.1016/s0140-6736(16)30054-x, DOI 10.1016/S0140-6736(16)30054-X]

[4] Macrophage-mediated inflammation in metabolic disease [J].

Chawla, Ajay ;

Nguyen, Khoa D. ;

Goh, Y. P. Sharon .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (11) :738-749

[5]

Cui XB, 2017, J BIOMED RES, V31, P1, DOI 10.7555/JBR.31.20160101

[6] An update on physical health and economic consequences of overweight and obesity [J].

Dinh-Toi Chu ;

Nguyen Thi Minh Nguyet ;

Thien Chu Dinh ;

Nguyen Vu Thai Lien ;

Khanh-Hoang Nguyen ;

Vo Truong Nhu Ngoc ;

Tao, Yang ;

Le Hoang Son ;

Duc-Hau Le ;

Vu Bich Nga ;

Jurgonski, Adam ;

Quoc-Hung Tran ;

Pham Van Tu ;

Van-Huy Pham .

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2018, 12 (06) :1095-1100

[7] LDL, LDL receptors, and PCSK9 as modulators of the risk for type 2 diabetes: a focus on white adipose tissue [J].

Faraj, May .

JOURNAL OF BIOMEDICAL RESEARCH, 2020, 34 (04) :251-259

[8] Trends in Obesity Among Adults in the United States, 2005 to 2014 [J].

Flegal, Katherine M. ;

Kruszon-Moran, Deanna ;

Carroll, Margaret D. ;

Fryar, Cheryl D. ;

Ogden, Cynthia L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (21) :2284-2291

[9] Adipogenesis and metabolic health [J].

Ghaben, Alexandra L. ;

Scherer, Philipp E. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2019, 20 (04) :242-258

[10] Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus [J].

Guilherme, Adilson ;

Henriques, Felipe ;

Bedard, Alexander H. ;

Czech, Michael P. .

NATURE REVIEWS ENDOCRINOLOGY, 2019, 15 (04) :207-225

← 1 2 3 4 →