Targeting malaria virulence and remodeling proteins to the host erythrocyte

被引：697

作者：

Marti, M ^{[1
]}

Good, RT ^{[1
]}

Rug, M ^{[1
]}

Knuepfer, E ^{[1
]}

Cowman, AF ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

SCIENCE | 2004年 / 306卷 / 5703期

关键词：

D O I：

10.1126/science.1102452

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to similar to8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.

引用

页码：1930 / 1933

页数：4

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