Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner

被引：57

作者：

Giacomini, Ana Cristina V. V. ^{[1
,2
]}

Abreu, Murilo S. ^{[1
]}

Zanandrea, Rodrigo ^{[2
]}

Saibt, Natalia ^{[1
]}

Friedrich, Maria Tereza ^{[2
]}

Koakoski, Gessi ^{[1
]}

Gusso, Darlan ^{[2
]}

Piato, Angelo L. ^{[3
]}

Barcellos, Leonardo J. G. ^{[1
,2
,4
]}

机构：

[1] Univ Fed Santa Maria, Programa Posgrad Farmacol, Av Roraima,1000,Cidade Univ, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Passo Fundo, BR 285, BR-99052900 Passo Fundo, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Farmacol & Terapeut, BR-90050170 Porto Alegre, RS, Brazil

[4] Univ Passo Fundo, Programa Posgrad Bioexpt, BR 285, BR-99052900 Passo Fundo, RS, Brazil

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

WASTE-WATER; ENRICHMENT; PHARMACEUTICALS; FLUOXETINE; FISH;

D O I：

10.1038/srep28986

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Here we provide evidence that both pharmacological and environmental manipulations similarly blunt the cortisol release in response to an acute stressor in adult zebrafish. Different groups of fish were maintained isolated or group-housed in barren or enriched tanks, and then exposed or not to diazepam or fluoxetine. Acute stress increased cortisol levels in group-housed zebrafish maintained in barren environment. Single-housed zebrafish displayed a blunted cortisol response to stress. Environmental enrichment also blunted the stress response and this was observed in both isolated and group-housed fish. The same blunting effect was observed in zebrafish exposed to diazepam or fluoxetine. We highlighted environmental enrichment as an alternative and/or complimentary therapeutic for reducing stress and as a promoter of animal welfare.

引用

页数：6

共 43 条

[1] Effects of waterborne fluoxetine on stress response and osmoregulation in zebrafish [J].