Recent Developments in the Synthesis of Pyrrolidine-Containing Iminosugars

被引：166

作者：

Stocker, Bridget L. ^{[1
]}

Dangerfield, Emma M. ^{[1
,2
]}

Win-Mason, Anna L. ^{[1
,2
]}

Haslett, Gregory W. ^{[1
,2
]}

Timmer, Mattie S. M. ^{[2
]}

机构：

[1] Malaghan Inst Med Res, Wellington, New Zealand

[2] Victoria Univ Wellington, Sch Chem & Phys Sci, Wellington, New Zealand

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 09期

关键词：

Azasugars; Iminosugars; Inhibitors; Total synthesis; RING-CLOSING METATHESIS; ALPHA-AMINO ALDEHYDES; 1ST ASYMMETRIC-SYNTHESIS; ONE-POT SYNTHESIS; UDP-GALF MIMICS; STEREOSELECTIVE-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; GLYCOSIDASE INHIBITORS; CONCISE SYNTHESIS;

D O I：

10.1002/ejoc.200901320

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As noted inhibitors of glycosidases, iminosugars have enormous therapeutic potential in the treatment of a number of diseases such as cancer, diabetes, and lysosomal storage disorders. Accordingly, much effort has been expended over the past decades in developing novel and efficient methodologies for the synthesis of iminosugars. This microreview highlights recent (post 2005) developments in the synthesis of pyrrolidine-containing iminosugars and includes discussions of methodologies such as ring-closing metathesis, aldol and pericyclic reactions, and protecting-group free strategies.

引用

页码：1615 / 1637

页数：23

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