Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies

被引：19

作者：

Pizzol, Damiano ^{[1
]}

Xiao, Tao ^{[2
]}

Smith, Lee ^{[3
]}

Lopez Sanchez, Guillermo F. ^{[5
]}

Garolla, Andrea ^{[6
]}

Parris, Christopher ^{[4
]}

Barnett, Yvonne ^{[4
]}

Ilie, Petre Cristian ^{[7
]}

Soysal, Pinar ^{[8
]}

Shin, Jae Il ^{[9
]}

Tully, Mark A. ^{[10
]}

Yang, Lin ^{[11
]}

Veronese, Nicola ^{[12
]}

Grabovac, Igor ^{[13
]}

机构：

[1] Italian Agcy Dev Cooperat, Khartoum, Sudan

[2] Shenzhen Univ, Coll Math & Stat, Shenzhen, Peoples R China

[3] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge CB1 1PT, England

[4] Anglia Ruskin Univ, Biomed Res Grp, Fac Sci & Engn, Cambridge, England

[5] Univ Murcia, Fac Sport Sci, Murcia, Spain

[6] Univ Padua, Dept Med, Unit Androl & Reprod Med, Padua, Italy

[7] Queen Elizabeth Hosp Kings Lynn NHS Fdn Trust, Kings Lynn, England

[8] Bezmialem Vakif Univ, Dept Geriatr Med, Istanbul, Turkey

[9] Yonsei Univ, Coll Med, Dept Paediat, Seoul, South Korea

[10] Ulster Univ, Sch Hlth Sci, Inst Mental Hlth Sci, Newtownabbey, North Ireland

[11] Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Holy Cross Ctr, Calgary, AB, Canada

[12] CNR, Neurosci Inst, Aging Branch, Padua, Italy

[13] Med Univ Vienna, Ctr Publ Hlth, Dept Social & Prevent Med, Vienna, Austria

来源：

BRITISH JOURNAL OF GENERAL PRACTICE | 2021年 / 71卷 / 706期

关键词：

erectile dysfunction; male cancer; meta-analysis; systematic review; prevalence; QUALITY-OF-LIFE; ANDROGEN DEPRIVATION THERAPY; LOCALIZED PROSTATE-CANCER; SEXUAL FUNCTION; RADICAL PROSTATECTOMY; TESTICULAR CANCER; INTERNATIONAL INDEX; BLADDER-CANCER; MEN; IMPACT;

D O I：

10.3399/bjgp20X714197

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Prevalence of erectile dysfunction (ED) in male survivors of cancer across cancer types has not been systematically analysed. Aim To estimate the prevalence of ED in all types of cancer and identify characteristics associated with ED in survivors of cancer. Design and setting Systematic review and meta-analysis (MA) of cross-sectional studies. Method MEDLINE, CINAHL, PsycINFO, and EMBASE were searched, targeting reports published from inception to 1 February 2020. All retrospective or prospective studies reporting prevalence of ED in male patients with cancer and using a validated tool for detection of ED were included. A random-effects MA model was used to pool prevalence of ED as absolute estimates at three different stages, that is, 'healthy', 'at diagnosis', and 'after treatment'. A univariate MA regression including the three-level group variable as the only independent variable was used to assess the difference in ED prevalence across the three groups. Further MAs were conducted for studies involving patients at diagnosis and after treatment, and statistical inferences were made with setting for multiple testing controlling for a false discovery rate (FDR) <0.05. Results In total, 1301 studies were assessed for inclusion. Of these, 141 were potentially eligible and subsequently scrutinised in full text. Finally, 43 studies were included with a total of 13 148 participants. Overall, pooled data of the included studies showed an ED prevalence of 40.72% (95% confidence interval [CI] = 31.80 to 50.29) in patients with cancer, with prevalences of 28.60% (95% CI = 12.10 to 53.83) at time of diagnosis and 42.70% (95% CI = 32.97 to 53.03) after treatment, with significant difference between these two stages and across cancer locations, controlling for an FDR < 0.05. Conclusion Erectile dysfunction was particularly high in male survivors of cancer and was associated with cancer treatment, cancer site, and age.

引用

页码：E372 / E380

页数：9

共 82 条

[1] Erectile dysfunction in successfully treated lymphoma patients [J].